Decoding nociceptor-DC dialogues

Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al.1 report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a “sentinel” DC program via the neuropeptide calcitonin gene-related peptide (CGRP), and enhan...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2023-05, Vol.56 (5), p.906-908
Main Authors: Crosson, Theo, Talbot, Sebastien
Format: Article
Language:English
Subjects:
Calcitonin Gene-Related Peptide
Dendritic Cells
Medicin och hälsovetenskap
Nociceptors - physiology
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Summary:Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al.1 report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a “sentinel” DC program via the neuropeptide calcitonin gene-related peptide (CGRP), and enhance DC inflammatory responses through direct connections. These neuroimmune units integrate nociceptors’ rapid responsiveness with DCs’ immune coordination, functioning as an advanced warning system. Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al.1 report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a “sentinel” DC program via the neuropeptide calcitonin gene-related peptide (CGRP), and enhance DC inflammatory responses through direct connections. These neuroimmune units integrate nociceptors’ rapid responsiveness with DCs’ immune coordination, functioning as an advanced warning system.
ISSN:1074-7613
1097-4180
1097-4180
DOI:10.1016/j.immuni.2023.04.016