Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells

( ) has been associated with cardiovascular diseases. The pro-inflammatory virulence factor cytotoxin-associated gene A (CagA) has been detected in serum exosomes of -infected subjects and may exert systemic effects throughout the cardiovascular system. The role of and CagA in vascular calcification...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-03, Vol.24 (6), p.5392
Main Authors: Sundqvist, Martin O, Wärme, Jonatan, Hofmann, Robin, Pawelzik, Sven-Christian, Bäck, Magnus
Format: Article
Language:English
Subjects:
Angina pectoris
Antigens, Bacterial - genetics
Antigens, Bacterial - metabolism
Atherosclerosis
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bone morphogenetic protein 2
Bone morphogenetic proteins
Calcification
Calcification (ectopic)
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Coronary artery
Coronary vessels
Coronary Vessels - metabolism
Cytokines
Cytotoxins - metabolism
Exosomes
Gene expression
Genes
Genetic aspects
Heart attacks
Helicobacter infections
Helicobacter Infections - complications
Helicobacter pylori
Humans
Inflammation
Inflammatory response
Interleukins
Phenotypes
Smooth muscle
Statistical significance
Vascular Calcification - complications
Vascular Calcification - genetics
Veins & arteries
Virulence
Virulence (Microbiology)
Virulence factors
Virulence Factors - genetics
Virulence Factors - metabolism
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Summary:( ) has been associated with cardiovascular diseases. The pro-inflammatory virulence factor cytotoxin-associated gene A (CagA) has been detected in serum exosomes of -infected subjects and may exert systemic effects throughout the cardiovascular system. The role of and CagA in vascular calcification was hitherto unknown. The aim of this study was to determine the vascular effects of CagA through human coronary artery smooth muscle cell (CASMC) osteogenic and pro-inflammatory effector gene expression as well as interleukin 1β secretion and cellular calcification. CagA upregulated bone morphogenic protein 2 (BMP-2) associated with an osteogenic CASMC phenotype switch and induced increased cellular calcification. Furthermore, a pro-inflammatory response was observed. These results support that may contribute to vascular calcification through CagA rendering CASMCs osteogenic and inducing calcification.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24065392