Associations between rheumatoid arthritis, incident heart failure, and left ventricular ejection fraction

Rheumatoid arthritis (RA) is an independent risk factor for heart failure (HF). Yet, the association between RA and left ventricular ejection fraction (LVEF) in incident HF is not well studied, nor are outcomes of HF in RA by LVEF. We identified incident HF patients between 2003 and 2018 through the...

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Bibliographic Details
Published in:The American heart journal 2023-05, Vol.259, p.42-51
Main Authors: Faxén, Jonas, Benson, Lina, Mantel, Ängla, Savarese, Gianluigi, Hage, Camilla, Dahlström, Ulf, Askling, Johan, Lund, Lars H., Andersson, Daniel C.
Format: Article
Language:English
Subjects:
Arthritis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - epidemiology
Cardiac arrhythmia
Comorbidity
Congestive heart failure
Demographics
Diagnosis
Ejection fraction
Heart failure
Heart Failure - complications
Humans
Inflammation
Medicin och hälsovetenskap
Mortality
Patients
Population
Population control
Prognosis
Regression analysis
Rheumatoid arthritis
Risk factors
Stroke Volume
Treatment Outcome
Vein & artery diseases
Ventricle
Ventricular Function, Left
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Summary:Rheumatoid arthritis (RA) is an independent risk factor for heart failure (HF). Yet, the association between RA and left ventricular ejection fraction (LVEF) in incident HF is not well studied, nor are outcomes of HF in RA by LVEF. We identified incident HF patients between 2003 and 2018 through the Swedish Heart Failure Registry, enriched with data from national health registers. Using logistic regression, associations between a prior diagnosis of RA and LVEF among HF patients and vs age, sex, and geographical area matched general population controls without HF were assessed. Additionally, associations between HF with vs without a prior diagnosis of RA, by LVEF, and outcomes up to 5 years after HF diagnosis were investigated using Cox regression. LVEF was primarily dichotomized at 40% and secondarily categorized as
ISSN:0002-8703
1097-6744
1097-6744
DOI:10.1016/j.ahj.2023.02.001