Active MMP-8 as a Biomarker of Peri-implant Health or Disease

• Published in: European journal of dentistry 2023-07, Vol.17 (3), p.924-928
• Main Authors: Xanthopoulou, Vithleem, Räisänen, Ismo, Sorsa, Timo, Sakellari, Dimitra
• Format: Article
• Language: English
• Subjects: Brief Report
• ISSN: 1305-7456; 1305-7464
• DOI: 10.1055/s-0042-1753454

Objectives This study investigated the potential of testing for active matrix metalloproteinase-8 (aMMP-8) by a quantitative point-of-care (PoC), chairside, lateral flow immunotest as a biomarker for the presence or absence of peri-implant diseases. Materials and Methods Eighty healthy patients with implants were recruited. The samples were collected from peri-implant sulcular fluid and quantitatively analyzed for aMMP-8. Clinical indices, which included probing depth, clinical attachment loss, bleeding on probing, and plaque, were recorded and radiographic assessments were performed. Statistical Analysis Comparisons of aMMP-8 levels and clinical parameters were analyzed by the Kruskal–Wallis test and the pairwise post hoc Dunn–Bonferroni test. A receiver operating curve analysis was used to analyze the diagnostic ability of aMMP-8 and the correlation between aMMP-8 and probing depth of the sampled site was sought by Spearman's rho and the coefficient of determination (R 2). Results Statistical analysis revealed statistically significant differences of aMMP-8 levels between the healthy and the mucositis and peri-implantitis groups, and between the mucositis and the peri-implantitis groups. Increasing probing depths of the sampled site and aMMP-8 levels were significantly correlated. Conclusions These data suggest that the aMMP-8 PoC test can be a beneficial adjunctive tool for early identification and screening of the risk of peri-implant diseases and progression.