Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges

Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson's dise...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2022-04, Vol.79 (4), p.219-219, Article 219
Main Authors: Han, Jinming, Chitu, Violeta, Stanley, E. Richard, Wszolek, Zbigniew K., Karrenbauer, Virginija Danylaité, Harris, Robert A.
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
Alzheimer's disease
Amyotrophic lateral sclerosis
Animal models
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Central nervous system
Cerebrospinal fluid
Colonies
Colony-stimulating factor
Colony-Stimulating Factors - pharmacology
Colony-Stimulating Factors - therapeutic use
Homeostasis
Huntington's disease
Huntingtons disease
Immune system
Inflammation
Inhibitors
Life Sciences
Medicin och hälsovetenskap
Microglia
Microglia - metabolism
Movement disorders
Multiple sclerosis
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - metabolism
Parkinson Disease - drug therapy
Parkinson's disease
Receptors
Review
Review Article
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Summary:Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson's disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS) and primary progressive multiple sclerosis (MS). Colony stimulating factor 1-receptor (CSF-1R) is predominantly expressed on microglia and its expression is significantly increased in neurodegenerative diseases. Cumulative findings have indicated that CSF-1R inhibitors can have beneficial effects in preclinical neurodegenerative disease models. Research using CSF-1R inhibitors has now been extended into non-human primates and humans. This review article summarizes the most recent advances using CSF-1R inhibitors in different neurodegenerative conditions including AD, PD, HD, ALS and MS. Potential challenges for translating these findings into clinical practice are presented.
ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-022-04225-1