Checkpoint CD47 expression in classical Hodgkin lymphoma

Summary The glycoprotein CD47 regulates antiphagocytic activity via signal regulatory protein alpha (SIRPa). This study investigated CD47 expression on Hodgkin and Reed–Sternberg (HRS) cells in the classical Hodgkin lymphoma (cHL) tumour microenvironment and its correlation with prognosis, programme...

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Published in:British journal of haematology 2022-06, Vol.197 (5), p.580-589
Main Authors: Gholiha, Alex Reza, Hollander, Peter, Löf, Liza, Glimelius, Ingrid, Hedstrom, Gustaf, Molin, Daniel, Hjalgrim, Henrik, Smedby, Karin E., Hashemi, Jamileh, Amini, Rose‐Marie, Enblad, Gunilla
Format: Article
Language:English
Subjects:
B7-H1 Antigen - metabolism
Biopsy
CD47
CD47 Antigen
Haematological malignancy ‐ Clinical
Hematology
Hodgkin Disease
Hodgkin lymphoma
Hodgkin's lymphoma
Humans
Immunohistochemistry
Leukocytes
Lymphoma
Medical prognosis
Medicin och hälsovetenskap
Microenvironments
PD-L1 protein
Prognosis
Reed-Sternberg Cells - metabolism
Research Paper
Signal regulatory protein-α
SIRPa
Statistical analysis
Tumor Microenvironment
Tumors
tumour markers
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Summary:Summary The glycoprotein CD47 regulates antiphagocytic activity via signal regulatory protein alpha (SIRPa). This study investigated CD47 expression on Hodgkin and Reed–Sternberg (HRS) cells in the classical Hodgkin lymphoma (cHL) tumour microenvironment and its correlation with prognosis, programmed‐death (PD) immune markers, and SIRPa+ leukocytes. We conducted immunohistochemistry with CD47 and SIRPa antibodies on diagnostic biopsies (tissue microarrays) from cHL patients from two cohorts (n = 178). In cohort I (n = 136) patients with high expression of CD47 on HRS cells (n = 48) had a significantly inferior event‐free survival [hazard ratio (HR) = 5.57; 95% confidence interval (CI), 2.78–11.20; p 
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/bjh.18137