Increased Risk of Suicide among Cancer Survivors Who Developed a Second Malignant Neoplasm

Background. Cancer diagnosis entails substantial psychological distress and is associated with dramatically increased risks of suicidal behaviors. However, little is known about the suicide risk among cancer survivors who developed a second malignant neoplasm (SMN). Methods. Using the Surveillance,...

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Bibliographic Details
Published in:Computational intelligence and neuroscience 2022, Vol.2022, p.2066133-11
Main Authors: Yang, Huazhen, Qu, Yuanyuan, Shang, Yanan, Wang, Chengshi, Wang, Junren, Lu, Donghao, Song, Huan
Format: Article
Language:English
Subjects:
Age
Alcohol
Calendars
Cancer
Cancer Survivors
Cancer therapies
Chemotherapy
Cohort Studies
Confidence intervals
Diagnosis
Epidemiology
Fatalities
Health aspects
Humans
Medical diagnosis
Medical research
Medical screening
Medicin och hälsovetenskap
Medicine, Experimental
Mortality
Neoplasms - complications
Patients
Population
Population studies
Psychological stress
Radiation therapy
Risk
Risk factors
Sociodemographic Factors
Statistical models
Stress (Psychology)
Suicidal behavior
Suicide
Suicides & suicide attempts
Surgery
Survival
Survival analysis
Tumors
Citations: Items that this one cites
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Summary:Background. Cancer diagnosis entails substantial psychological distress and is associated with dramatically increased risks of suicidal behaviors. However, little is known about the suicide risk among cancer survivors who developed a second malignant neoplasm (SMN). Methods. Using the Surveillance, Epidemiology, and End Results database, we conducted a population-based cohort study involving 7,824,709 patients with first malignant neoplasm (FMN). We measured the hazard ratios (HRs) of suicide death after receiving a SMN diagnosis using Cox proportional hazard models, as compared with patients with FMN. The comparison with the US population was achieved by calculating standardized mortality ratios (SMRs). Results. Totally 685,727 FMN patients received a diagnosis of SMN during follow-up, and we in total identified 10,930 and 937 suicide deaths among FMN and SMN patients, respectively. The HR of suicide deaths was 1.23 (95% confidence interval (CI), 1.14–1.31) after a SMN diagnosis, compared with FMN patients, after adjusting for sociodemographic factors, tumor characteristics, and cancer treatment. As compared with the general population, while both SMN and FMN patients suffered an increased risk of suicide deaths, the excess risk was higher among SMN patients than FMN patients (age-, sex-, and calendar-year-adjusted SMR 1.65 (95% CI 1.54–1.75) vs. 1.29 (95% CI 1.26–1.31); Pdifference
ISSN:1687-5265
1687-5273
1687-5273
DOI:10.1155/2022/2066133