Tumour-infiltrating lymphocytes in oropharyngeal cancer: a validation study according to the criteria of the International Immuno-Oncology Biomarker Working Group

Background The evaluation of immune response can aid in prediction of cancer behaviour. Here, we assessed the prognostic significance of tumour-infiltrating lymphocytes (TILs) in oropharyngeal squamous cell carcinoma (OPSCC). Methods A total of 182 patients treated for OPSCC were included in this st...

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Bibliographic Details
Published in:British journal of cancer 2022-06, Vol.126 (11), p.1589-1594
Main Authors: Almangush, Alhadi, Jouhi, Lauri, Atula, Timo, Haglund, Caj, Mäkitie, Antti A., Hagström, Jaana, Leivo, Ilmo
Format: Article
Language:English
Subjects:
631/67/1536
692/53/2422
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cancer immunotherapy
Cancer och onkologi
Cancer Research
Drug Resistance
Epidemiology
Head and Neck Neoplasms - pathology
Human papillomavirus
Humans
Immune response
Klinisk medicin
Lymphocytes
Lymphocytes, Tumor-Infiltrating
Medicin och hälsovetenskap
Molecular Medicine
Oncology
Oropharyngeal cancer
Oropharyngeal Neoplasms - pathology
Oto-rino-laryngologi
Papillomavirus Infections - complications
Prognosis
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - pathology
Throat cancer
Tumors
Working groups
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Summary:Background The evaluation of immune response can aid in prediction of cancer behaviour. Here, we assessed the prognostic significance of tumour-infiltrating lymphocytes (TILs) in oropharyngeal squamous cell carcinoma (OPSCC). Methods A total of 182 patients treated for OPSCC were included in this study. Assessment of TILs was conducted on tumour sections stained with standard haematoxylin and eosin (HE) staining. We used the scoring criteria proposed by the International Immuno-Oncology Biomarker Working Group. Results The multivariable analysis showed that TILs associated with disease-specific survival with a hazard ratio (HR) of 2.13 (95% CI 1.14–3.96; P  = 0.017). Similarly, TILs associated significantly with overall survival with HR of 1.87 (95% CI 1.11–3.13; P  = 0.018). In a sub-analysis of HPV-positive and HPV-negative cases separately, TILs showed a significant prognostic value in both groups ( P  
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-022-01708-7