Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patie...

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Bibliographic Details
Published in:Journal of cardiovascular translational research 2022-08, Vol.15 (4), p.692-707
Main Authors: Marlevi, David, Mariscal-Harana, Jorge, Burris, Nicholas S., Sotelo, Julio, Ruijsink, Bram, Hadjicharalambous, Myrianthi, Asner, Liya, Sammut, Eva, Chabiniok, Radomir, Uribe, Sergio, Winter, Reidar, Lamata, Pablo, Alastruey, Jordi, Nordsletten, David
Format: Article
Language:English
Subjects:
4D flow MRI
Aorta - diagnostic imaging
Aortic hemodynamics
Aortic relative pressure
Aortic stiffness
Bioengineering
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Cardiomyopathy, Dilated
Dilated cardiomyopathy
Heart Ventricles
Hemodynamics
Human Genetics
Humans
Life Sciences
Magnetic Resonance Imaging - methods
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Original
Original Article
Ventricular Function, Left
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Summary:Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr
ISSN:1937-5387
1937-5395
1937-5395
DOI:10.1007/s12265-021-10181-1