Metformin therapy is not associated with the lower prevalence of ascending aortic aneurysm in diabetic patients

Abstract   OBJECTIVES Metformin therapy has previously been associated with reduced abdominal aortic aneurysm growth rate in diabetic patients and shown to suppress the formation and progression of abdominal aortic aneurysm in normoglycemic mice. Here, we investigated the association between Metform...

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Published in:European journal of cardio-thoracic surgery 2022-01, Vol.61 (2), p.388-392
Main Authors: Vignac, Maxime, Ntika, Stelia, Olsson, Christian, Franco-Cereceda, Anders, Björck, Hanna M
Format: Article
Language:English
Subjects:
Animals
Aortic Aneurysm - epidemiology
Aortic Aneurysm - surgery
Aortic Aneurysm, Abdominal - epidemiology
Aortic Valve - surgery
Diabetes Mellitus
Humans
Medicin och hälsovetenskap
Metformin - therapeutic use
Mice
Prevalence
Retrospective Studies
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container_issue 2
container_start_page 388
container_title European journal of cardio-thoracic surgery
container_volume 61
creator Vignac, Maxime
Ntika, Stelia
Olsson, Christian
Franco-Cereceda, Anders
Björck, Hanna M
description Abstract   OBJECTIVES Metformin therapy has previously been associated with reduced abdominal aortic aneurysm growth rate in diabetic patients and shown to suppress the formation and progression of abdominal aortic aneurysm in normoglycemic mice. Here, we investigated the association between Metformin treatment and prevalence of aneurysm in the ascending aorta (AscAA). METHODS A total of 734 patients undergoing open-heart surgery for AscAA and/or aortic valve disease were studied. Diabetes status and medication use were self-reported by the patients in a systematic questionnaire. Aortic dilatation was defined as an aortic root or ascending aortic diameter ≥4.0 cm. High-sensitivity C-reactive protein levels were assessed as a measure of systemic inflammation. RESULTS We could confirm the inverse association between diabetes and AscAA prevalence (16% vs 43.9%, for diabetic and non-diabetic patients, respectively; Odds ratio 0.243; 95% CI, 0.129–0.460, P 
doi_str_mv 10.1093/ejcts/ezab435
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Here, we investigated the association between Metformin treatment and prevalence of aneurysm in the ascending aorta (AscAA). METHODS A total of 734 patients undergoing open-heart surgery for AscAA and/or aortic valve disease were studied. Diabetes status and medication use were self-reported by the patients in a systematic questionnaire. Aortic dilatation was defined as an aortic root or ascending aortic diameter ≥4.0 cm. High-sensitivity C-reactive protein levels were assessed as a measure of systemic inflammation. RESULTS We could confirm the inverse association between diabetes and AscAA prevalence (16% vs 43.9%, for diabetic and non-diabetic patients, respectively; Odds ratio 0.243; 95% CI, 0.129–0.460, P &lt; 0.001). Furthermore, in diabetic patients, Metformin treatment was associated with lower high-sensitivity C-reactive protein levels. There was, however, no difference in the prevalence of AscAA among diabetic patients with and without Metformin treatment (16% vs 16% for treated and non-treated patients, respectively; OR 1.039; 95% CI 0.26–4.19, P = 0.957). CONCLUSIONS Our data do not support a protective effect of Metformin therapy in AscAA formation. Subj collection 161, 173 Population-based studies suggest that diabetes mellitus has a protective effect on aortic aneurysm formation [1, 2], possibly via actions attributable to the antidiabetic agent Metformin.</description><identifier>ISSN: 1010-7940</identifier><identifier>ISSN: 1873-734X</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1093/ejcts/ezab435</identifier><identifier>PMID: 34676406</identifier><language>eng</language><publisher>Germany: Oxford University Press</publisher><subject>Animals ; Aortic Aneurysm - epidemiology ; Aortic Aneurysm - surgery ; Aortic Aneurysm, Abdominal - epidemiology ; Aortic Valve - surgery ; Diabetes Mellitus ; Humans ; Medicin och hälsovetenskap ; Metformin - therapeutic use ; Mice ; Prevalence ; Retrospective Studies</subject><ispartof>European journal of cardio-thoracic surgery, 2022-01, Vol.61 (2), p.388-392</ispartof><rights>The Author(s) 2021. 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Here, we investigated the association between Metformin treatment and prevalence of aneurysm in the ascending aorta (AscAA). METHODS A total of 734 patients undergoing open-heart surgery for AscAA and/or aortic valve disease were studied. Diabetes status and medication use were self-reported by the patients in a systematic questionnaire. Aortic dilatation was defined as an aortic root or ascending aortic diameter ≥4.0 cm. High-sensitivity C-reactive protein levels were assessed as a measure of systemic inflammation. RESULTS We could confirm the inverse association between diabetes and AscAA prevalence (16% vs 43.9%, for diabetic and non-diabetic patients, respectively; Odds ratio 0.243; 95% CI, 0.129–0.460, P &lt; 0.001). Furthermore, in diabetic patients, Metformin treatment was associated with lower high-sensitivity C-reactive protein levels. There was, however, no difference in the prevalence of AscAA among diabetic patients with and without Metformin treatment (16% vs 16% for treated and non-treated patients, respectively; OR 1.039; 95% CI 0.26–4.19, P = 0.957). CONCLUSIONS Our data do not support a protective effect of Metformin therapy in AscAA formation. 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Here, we investigated the association between Metformin treatment and prevalence of aneurysm in the ascending aorta (AscAA). METHODS A total of 734 patients undergoing open-heart surgery for AscAA and/or aortic valve disease were studied. Diabetes status and medication use were self-reported by the patients in a systematic questionnaire. Aortic dilatation was defined as an aortic root or ascending aortic diameter ≥4.0 cm. High-sensitivity C-reactive protein levels were assessed as a measure of systemic inflammation. RESULTS We could confirm the inverse association between diabetes and AscAA prevalence (16% vs 43.9%, for diabetic and non-diabetic patients, respectively; Odds ratio 0.243; 95% CI, 0.129–0.460, P &lt; 0.001). Furthermore, in diabetic patients, Metformin treatment was associated with lower high-sensitivity C-reactive protein levels. There was, however, no difference in the prevalence of AscAA among diabetic patients with and without Metformin treatment (16% vs 16% for treated and non-treated patients, respectively; OR 1.039; 95% CI 0.26–4.19, P = 0.957). CONCLUSIONS Our data do not support a protective effect of Metformin therapy in AscAA formation. Subj collection 161, 173 Population-based studies suggest that diabetes mellitus has a protective effect on aortic aneurysm formation [1, 2], possibly via actions attributable to the antidiabetic agent Metformin.</abstract><cop>Germany</cop><pub>Oxford University Press</pub><pmid>34676406</pmid><doi>10.1093/ejcts/ezab435</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5677-0747</orcidid><orcidid>https://orcid.org/0000-0002-9155-3609</orcidid><orcidid>https://orcid.org/0000-0001-5621-1446</orcidid><oa>free_for_read</oa></addata></record>
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source Oxford Journals Online
subjects Animals
Aortic Aneurysm - epidemiology
Aortic Aneurysm - surgery
Aortic Aneurysm, Abdominal - epidemiology
Aortic Valve - surgery
Diabetes Mellitus
Humans
Medicin och hälsovetenskap
Metformin - therapeutic use
Mice
Prevalence
Retrospective Studies
title Metformin therapy is not associated with the lower prevalence of ascending aortic aneurysm in diabetic patients
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