Increasing the resting time between drop jumps lessens delayed-onset muscle soreness and limits the extent of prolonged low-frequency force depression in human knee extensor muscles

Purpose Unaccustomed eccentric contractions generally result in a long-lasting contractile impairment, referred to as prolonged low-frequency force depression (PLFFD), and delayed-onset muscle soreness (DOMS). We here used repeated drop jumps (DJs) as an eccentric contraction model and studied the e...

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Bibliographic Details
Published in:European journal of applied physiology 2022, Vol.122 (1), p.255-266
Main Authors: Kamandulis, Sigitas, Mickevicius, Mantas, Snieckus, Audrius, Streckis, Vytautas, Montiel-Rojas, Diego, Chaillou, Thomas, Westerblad, Hakan, Venckunas, Tomas
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Biopsy
Biopsy, Needle
Creatine Kinase - blood
Electric Stimulation
Electrical stimulation
Extracellular matrix
Human Physiology
Humans
Kinases
Knee
Knee - physiology
Low-frequency fatigue
Male
Medicin och hälsovetenskap
mRNA
Muscle contraction
Muscle Contraction - physiology
Myalgia - prevention & control
Occupational Medicine/Industrial Medicine
Original Article
Pain Measurement
Physiology
Proteins
Rest
Sarcomere damage
Sports Medicine
Stretch–shortening cycle exercise
Time Factors
Torque
Young Adult
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Summary:Purpose Unaccustomed eccentric contractions generally result in a long-lasting contractile impairment, referred to as prolonged low-frequency force depression (PLFFD), and delayed-onset muscle soreness (DOMS). We here used repeated drop jumps (DJs) as an eccentric contraction model and studied the effects of increasing the time between DJs from 20 s to 5 min. We hypothesized that both PLFFD and DOMS would be less marked at the longer DJ interval due to the longer time to restore structural elements between DJs. Methods Young men ( n  = 12) randomly performed 50 DJs with either 20-s (DJ-20 s) or 5-min (DJ-5 min) rest between DJs. Voluntary, 20 Hz and 100 Hz electrically stimulated isometric knee extension torques and muscle soreness were monitored before and for 7 days after DJs; serum CK activity was measured to assess muscle fibre protein leakage. In additional experiments, changes in mRNA levels were assessed in muscle biopsies collected before and 1 h after exercise. Results A marked PLFFD was observed with both protocols and the extent of 20 Hz torque depression was smaller immediately and 1 day after DJ-5 min than after DJ-20 s ( p  
ISSN:1439-6319
1439-6327
1439-6327
DOI:10.1007/s00421-021-04834-x