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Low hand grip strength is associated with worse functional capacity and higher inflammation in people receiving maintenance hemodialysis

•People with low hand grip strength show worse functional capacity and higher inflammation.•Hand grip strength and muscle quality index are more strongly associated with clinical measure than lean mass is.•Age, muscle mass, nutritional status, and gender are predictors of hand grip strength. To eval...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2022-01, Vol.93, p.111469-111469, Article 111469
Main Authors: Lopes, Lorena Cristina Curado, Gonzalez, Maria Cristina, Avesani, Carla Maria, Prado, Carla M., Peixoto, Maria do Rosário Gondim, Mota, João Felipe
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Language:English
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Summary:•People with low hand grip strength show worse functional capacity and higher inflammation.•Hand grip strength and muscle quality index are more strongly associated with clinical measure than lean mass is.•Age, muscle mass, nutritional status, and gender are predictors of hand grip strength. To evaluate the associations of hand grip strength (HGS) with body composition, functional capacity, muscle quality, and inflammatory markers in people receiving maintenance hemodialysis. This is a cross-sectional study in people receiving maintenance hemodialysis. HGS was measured by hydraulic dynamometer on the upper limb without fistula. Participants were stratified into low or adequate HGS, based on population-specific cutoff points. Body composition was assessed by dual-energy X-ray absorptiometry, and functional capacity by the Short Physical Performance Battery and timed up-and-go tests. In addition, serum creatinine, interleukin-6 (IL-6), IL-10, tumor necrosis factor-α, and ultra-sensitive C-reactive protein (us-CRP) were measured before the dialysis session. A total of 67 participants (41.8% women, 58.2% male; ages 54.1 ± 11.7 y) were included. Those with low HGS had worse functional capacity than those with adequate HGS (timed up-and-go test, 10.7 ± 1.0 versus 8.5 ± 0.8 sec, respectively; P < 0.001). IL-6 and us-CRP were higher in those with low HGS than their counterparts (IL-6: 2.7 ± 0.3 versus 1.9 pg/mL, P = 0.03; us-CRP: 14.8 ± 3.0 versus 4.7 ± 1.9 mg/L, P = 0.03). Multiple linear regression analysis showed that appendicular lean mass, us-CRP, age, sex, and seven-point subjective global assessment score were associated with HGS. Participants with low HGS showed higher inflammation and lower functional capacity. In addition to muscle mass, inflammation and nutritional status also affect HGS.
ISSN:0899-9007
1873-1244
1873-1244
DOI:10.1016/j.nut.2021.111469