Continuous Monitoring Reveals Protective Effects of N‐Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit

Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with the goal of providing more human‐like models for biopharmaceutical research. In this study, the first such model of the blood‐brain barrier (BBB‐on‐chip) featuring both isogenic human induced pluripotent stem ce...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-08, Vol.17 (32), p.e2101785-n/a
Main Authors: Matthiesen, Isabelle, Voulgaris, Dimitrios, Nikolakopoulou, Polyxeni, Winkler, Thomas E., Herland, Anna
Format: Article
Language:English
Subjects:
Antioxidants
Biomaterials
Biotechnology
Bioteknologi
continuous monitoring
Electrical Engineering
Elektro- och systemteknik
General Chemistry
General Materials Science
Glutathione
human‐induced pluripotent stem cells
Medicin och hälsovetenskap
microphysiological systems
Monitoring
Nanotechnology
Network analysis
neurovascular unit
oxidative and nitrosative stress
Polydimethylsiloxane
Prophylaxis
Stem cells
Stoichiometry
Substrates
Temporal resolution
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Summary:Microphysiological systems mimic the in vivo cellular ensemble and microenvironment with the goal of providing more human‐like models for biopharmaceutical research. In this study, the first such model of the blood‐brain barrier (BBB‐on‐chip) featuring both isogenic human induced pluripotent stem cell (hiPSC)‐derived cells and continuous barrier integrity monitoring with
ISSN:1613-6810
1613-6829
1613-6829
DOI:10.1002/smll.202101785