Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation

Whether renal function is causally associated with venous thromboembolism (VTE) is not yet fully elucidated. We conducted a two-sample Mendelian randomization (MR) study to determine the causal effect of renal function, measured as estimated glomerular filtration rate (eGFR), on VTE. Single-nucleoti...

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Bibliographic Details
Published in:Journal of thrombosis and thrombolysis 2022-01, Vol.53 (1), p.43-50
Main Authors: Yuan, Shuai, Bruzelius, Maria, Larsson, Susanna C.
Format: Article
Language:English
Subjects:
Biobanks
Cardiology
Epidermal growth factor receptors
Estimated glomerular filtration rate
Genome-wide association studies
Genome-Wide Association Study
Genomes
Glomerular Filtration Rate
Hematology
Humans
Kidney - physiopathology
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Mendelian Randomization Analysis
Meta-analysis
Pleiotropy
Polymorphism, Single Nucleotide
Renal function
Sensitivity analysis
Single-nucleotide polymorphism
Thromboembolism
Venous thromboembolism
Venous Thromboembolism - genetics
Venous Thromboembolism - physiopathology
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Summary:Whether renal function is causally associated with venous thromboembolism (VTE) is not yet fully elucidated. We conducted a two-sample Mendelian randomization (MR) study to determine the causal effect of renal function, measured as estimated glomerular filtration rate (eGFR), on VTE. Single-nucleotide polymorphisms associated with eGFR were selected as instrumental variables at the genome-wide significance level ( p  
ISSN:0929-5305
1573-742X
1573-742X
DOI:10.1007/s11239-021-02494-4