Acute kidney injury and mortality risk in older adults with COVID-19

• Published in: Journal of nephrology 2021, Vol.34 (2), p.295-304
• Main Authors: Xu, Hong, Garcia-Ptacek, Sara, Annetorp, Martin, Bruchfeld, Annette, Cederholm, Tommy, Johnson, Peter, Kivipelto, Miia, Metzner, Carina, Religa, Dorota, Eriksdotter, Maria
• Format: Article
• Language: English
• Subjects: Acute kidney injury; Acute Kidney Injury - etiology; Acute Kidney Injury - mortality; Aged, 80 and over; COVID-19; COVID-19 - complications; COVID-19 - epidemiology; Female; Hospital Mortality - trends; Humans; In-hospital death; Incidence; Male; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Nephrology; Older adults; Original; Original Article; Pandemics; Retrospective Studies; Risk Assessment - methods; Risk Factors; Survival Rate - trends; Sweden - epidemiology; Urology
• ISSN: 1121-8428; 1724-6059; 1724-6059
• DOI: 10.1007/s40620-021-01022-0

Background Research regarding COVID-19 and acute kidney injury (AKI) in older adults is scarce. We evaluated risk factors and outcomes of AKI in hospitalized older adults with and without COVID-19. Methods Observational study of patients admitted to two geriatric clinics in Stockholm from March 1st to June 15th, 2020. The difference in incidence, risk factors and adverse outcomes for AKI between patients with or without COVID-19 were examined. Odds ratios (OR) for the risk of AKI and in-hospital death were obtained from logistic regression. Results Three hundred-sixteen older patients were hospitalized for COVID-19 and 876 patients for non-COVID-19 diagnoses. AKI occurred in 92 (29%) patients with COVID-19 vs. 159 (18%) without COVID-19. The odds for developing AKI were higher in patients with COVID-19 (adjusted OR, 1.70; 95% confidence interval [CI] 1.04–2.76), low baseline kidney function as depicted by estimated glomerular filtration rate (eGFR) [4.19 (2.48–7.05), for eGFR 30 to