The Neuroimmunology of Chronic Pain: From Rodents to Humans

Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling betw...

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Bibliographic Details
Published in:The Journal of neuroscience 2021-02, Vol.41 (5), p.855-865
Main Authors: Grace, Peter M, Tawfik, Vivianne L, Svensson, Camilla I, Burton, Michael D, Loggia, Marco L, Hutchinson, Mark R
Format: Article
Language:English
Subjects:
Animal models
Animals
Arthritis
Autoantibodies - immunology
Autoantibodies - metabolism
Chronic pain
Chronic Pain - immunology
Chronic Pain - metabolism
Disease Models, Animal
Fibromyalgia
Humans
Immune system
Low back pain
Neuralgia
Neuroglia - immunology
Neuroglia - metabolism
Neuroimmunology
Neuroimmunomodulation - physiology
Neuronal-glial interactions
Neurons
Neurons - immunology
Neurons - metabolism
NF-E2-Related Factor 2 - immunology
NF-E2-Related Factor 2 - metabolism
Pain
Rodentia
Rodents
Signaling
Symposium/Mini-Symposium
Therapeutic targets
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Summary:Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.1650-20.2020