Peri-implant treatment reduces the salivary levels of Colony stimulator factor-1 and S100A8/A9

[Abstract] This study evaluated the impact of peri-implant treatment in the salivary levels of Colony stimulator factor-1 (CSF-1), S100A8/A9 and S100A12 in patients having mucositis or peri-implantitis. As a secondary aim, we analysed the correlation between the salivary and peri-implant crevicular...

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Bibliographic Details
Published in:Odontology 2021-04, Vol.109 (2), p.540-546
Main Authors: de Mello-Neto, João Martins, Teixeira, Mayla Kezy Silva, Teixeira, Glaucia Schuindt, Lourenço, Eduardo José Veras, Telles, Daniel Moraes, Lira-Junior, Ronaldo, Ipe, Deepak, Nair, Raj G., Boström, Elisabeth Almer, Figueredo, Carlos Marcelo
Format: Article
Language:English
Subjects:
Aged
Dental Implants
Dentistry
Enzyme-Linked Immunosorbent Assay
Gingival Crevicular Fluid
Humans
Medicin och hälsovetenskap
Medicine
Middle Aged
Oral and Maxillofacial Surgery
Original Article
Peri-Implantitis - therapy
Saliva
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Summary:[Abstract] This study evaluated the impact of peri-implant treatment in the salivary levels of Colony stimulator factor-1 (CSF-1), S100A8/A9 and S100A12 in patients having mucositis or peri-implantitis. As a secondary aim, we analysed the correlation between the salivary and peri-implant crevicular fluid (PICF) levels. Forty-seven patient, 27 having mucositis (mean age 63.11+-7.78) and 20 having peri-implantitis (61.25+-7.01) participated in the study. Clinical parameters, probing pocket depth, clinical attachment level, % of plaque and bleeding on probing were evaluated. Unstimulated whole saliva was collected from all patients, while PICF was collected only from a patient's subgroup (n=20). Samples were collected before and 3 months after peri-implant treatment. Enzyme-linked immunosorbent assays determined levels of CSF-1, S100A8/A9 and S100A12. Clinical parameters improved and salivary levels of CSF-1 and S100A8/A9, but not S100A12, reduced significantly after treatment in both groups. No significant correlation was found in the salivary and PICF levels of the same molecule. In conclusion, the treatment of peri-implant disease significantly improved the clinical parameters and reduced the salivary levels of CSF-1 and S100A8/A9. The salivary expressions of CSF-1, S100A8/A9 and S100A12 did not correlate with their own expression in PICF.
ISSN:1618-1247
1618-1255
1618-1255
DOI:10.1007/s10266-020-00570-4