Vitamin D levels and busulphan kinetics in patients undergoing hematopoietic stem cell transplantation, a multicenter study

Vitamin D (Vit-D), an essential nutrient, interacts with different drugs including chemotherapeutic agents like busulphan, an alkylating agent used for conditioning prior to stem cell transplantation. The correlation between Vit-D plasma levels and busulphan clearance was investigated in an uncontro...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2021-04, Vol.56 (4), p.807-817
Main Authors: El-Serafi, Ahmed, He, Rui, Zheng, Wenyi, Benkossou, Fadwa, Oerther, Sandra, Zhao, Ying, Mellgren, Karin, Gustafsson, Britt, Heilmann, Carsten, Kanerva, Jukka, Lotfi, Kourosh, Toporski, Jacek, Sundin, Mikael, Höglund, Martin, Mattsson, Jonas, El-Serafi, Ibrahim, Hassan, Moustapha
Format: Article
Language:English
Subjects:
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Adult
Adults
Alfacalcidol
Alkylation
Animals
Busulfan
Calcifediol
Calciferol
Cell Biology
Chemotherapy
Children
Correlation
Dietary supplements
Dosage and administration
Drug interactions
Health aspects
Hematology
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
Immunosuppressive agents
Internal Medicine
Intravenous administration
Kinetics
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Mice
Observations
Pharmacokinetics
Pharmacology
Plasma levels
Prospective Studies
Public Health
Stem cell research
Stem cell transplantation
Stem Cells
Transplantation
Vitamin D
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Summary:Vitamin D (Vit-D), an essential nutrient, interacts with different drugs including chemotherapeutic agents like busulphan, an alkylating agent used for conditioning prior to stem cell transplantation. The correlation between Vit-D plasma levels and busulphan clearance was investigated in an uncontrolled prospective study in patients and mice. Plasma 25(OH)D levels were measured and busulphan pharmacokinetics calculated in 81 patients. Adults received oral busulphan ( n  = 34) while children received busulphan orally ( n  = 19) or intravenously ( n  = 28). Patients received no Vit-D supplementation. To confirm our findings, pharmacokinetics after a single dose of busulphan (oral or intravenous) were evaluated in two groups of mice ( n  = 60) receiving high or standard-level Vit-D supplementation. Both busulphan clearance ( P  
ISSN:0268-3369
1476-5365
1476-5365
DOI:10.1038/s41409-020-01091-y