Transcription Factor Profiling Identifies Spatially Heterogenous Mediators of Follicular Thyroid Cancer Invasion

While minimally invasive follicular thyroid cancer (miFTC) generally has low risk of recurrence or death, encapsulated angioinvasive (eaFTC) or widely invasive (wiFTC) histological subtypes display significantly worse prognosis. Drivers of invasion are incompletely understood. Therefore, tissue samp...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine pathology 2020-12, Vol.31 (4), p.367-376
Main Authors: Nicolson, Norman G., Paulsson, Johan O., Juhlin, C. Christofer, Carling, Tobias, Korah, Reju
Format: Article
Language:English
Subjects:
Acetylation
Drug development
Endocrinology
Gene expression
Histones
Immunohistochemistry
Immunomodulation
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Oncology
Pathology
Sp1 protein
Thyroid cancer
Transcription factors
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:While minimally invasive follicular thyroid cancer (miFTC) generally has low risk of recurrence or death, encapsulated angioinvasive (eaFTC) or widely invasive (wiFTC) histological subtypes display significantly worse prognosis. Drivers of invasion are incompletely understood. Therefore, tissue samples including miFTC, eaFTC, and wiFTC tumors, as well as histologically normal thyroid adjacent to benign follicular adenomas, were selected from a cohort ( n  = 21) of thyroid tumor patients, and the gene expression of selected transcription factors was characterized with quantitative PCR. Invasion-relevant spatial expression patterns of selected transcription factors were subsequently characterized with immunohistochemistry. E2F1 was over-expressed in all 3 subtypes ( p
ISSN:1046-3976
1559-0097
1559-0097
DOI:10.1007/s12022-020-09651-0