Dysphonia and dysphagia as early manifestations of autoimmune inflammatory myopathy

While dysphagia is a recognized manifestation of autoimmune inflammatory myopathy, a relationship between myositis and dysphonia or laryngeal pathology is not well-documented. We therefore sought to describe the spectrum of laryngeal disorders present in myositis patients, evaluate whether any speci...

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Bibliographic Details
Published in:American journal of otolaryngology 2021-01, Vol.42 (1), p.102747-102747, Article 102747
Main Authors: Weinreb, Samuel F., Piersiala, Krzysztof, Hillel, Alexander T., Akst, Lee M., Best, Simon R.
Format: Article
Language:English
Subjects:
Age
Age Factors
Autoimmune Diseases - complications
Autoimmune Diseases - diagnosis
Deglutition disorders
Deglutition Disorders - epidemiology
Deglutition Disorders - etiology
Dermatomyositis
Diagnostic systems
Disorders
Dysphagia
Dysphonia
Dysphonia - epidemiology
Dysphonia - etiology
Early Diagnosis
Electronic health records
Electronic medical records
Evaluation
Female
Humans
Inflammation
Inflammatory diseases
Male
Medical records
Medicin och hälsovetenskap
Middle Aged
Musculoskeletal diseases
Myopathy
Myositis
Myositis - complications
Myositis - diagnosis
Ostomy
Pathology
Patients
Polymyositis
Quality of Life
Regression analysis
Regression models
Retrospective Studies
Sex Factors
Signs and symptoms
Smoking
Velopharyngeal insufficiency
Voice
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Description
Summary:While dysphagia is a recognized manifestation of autoimmune inflammatory myopathy, a relationship between myositis and dysphonia or laryngeal pathology is not well-documented. We therefore sought to describe the spectrum of laryngeal disorders present in myositis patients, evaluate whether any specific conditions are overrepresented among these patients compared to a large treatment-seeking population, and examine the clinical course and outcomes of these symptoms. This was a retrospective chart review, including all patients seen at the Johns Hopkins Voice Center between January 2016 and December 2017. Demographic data, comorbidities, and laryngeal diagnoses were extracted from the electronic medical record. The charts of patients with myositis were reviewed further to ascertain details of their laryngeal symptoms and myositis disease course. Associations between myositis and dysphonia/dysphagia were evaluated using binary regression and multinomial logistic regression models to adjust for age, sex, race, and smoking status. Of 4252 patients, sixteen had myositis. Compared to 4236 controls, these patients had significantly higher odds of presenting with muscular voice disorders (adjusted odds ratio (OR*) = 4.503, p* = 0.005) and dysphagia (OR* = 6.823, p* 
ISSN:0196-0709
1532-818X
1532-818X
DOI:10.1016/j.amjoto.2020.102747