HPV Types in Cervical Precancer by HIV Status and Birth Region: A Population-Based Register Study

• Published in: Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-12, Vol.29 (12), p.2662-2668
• Main Authors: Carlander, Christina, Lagheden, Camilla, Eklund, Carina, Nordqvist Kleppe, Sara, Dzabic, Mensur, Wagner, Philippe, Yilmaz, Aylin, Elfgren, Kristina, Sönnerborg, Anders, Sparén, Pär, Dillner, Joakim
• Format: Article
• Language: English
• Subjects: Adult; cancer; Cancer and Oncology; Cancer och onkologi; Environmental & Occupational Health; Female; Genotype; health; HIV Infections - complications; human-papillomavirus; Humans; impact; infected women; intraepithelial neoplasia; migrants; multiple types; Oncology; Papillomavirus Infections - complications; positive women; Public; risk; Uterine Cervical Neoplasms - etiology; Uterine Cervical Neoplasms - virology
• ISSN: 1055-9965; 1538-7755; 1538-7755
• DOI: 10.1158/1055-9965.EPI-20-0969

Data are lacking regarding which human papillomavirus (HPV) types cause high-grade cervical neoplasia (CIN2+) in people with HIV in Europe. We assessed which HPV types are associated with CIN2+ in women living in Sweden by HIV status. The Swedish National HIV Registry, the Swedish Population Registry, and the Swedish National Cervical Screening Registry were linked. CIN2+ tissue blocks of 130 women living with HIV (WLWH) and 234 HIV-negative women, matched for country of birth (1:2), were retrieved from bio-banks and HPV genotyped. Adjusted ORs (adjOR), stratified by country of birth, were calculated using conditional logistic regression. Matching was broken for cross-group comparisons. WLWH with CIN2 were less likely to have HPV16 [14% vs. 40%; adjOR 0.1; 95% confidence interval (CI), 0.04-0.56] than HIV-negative women, but among women with CIN3, there was no difference in HPV16 prevalence by HIV status (adjOR 0.9; 95% CI, 0.51-1.70). WLWH were six times more likely to have HPV35 in CIN3 than HIV-negative women (adjOR 6.2; 95% CI, 1.3-30.4). WLWH from sub-Saharan Africa (SSA) had less 9-valent vaccine types, compared with both HIV-negative women born in Sweden (adjOR 0.1; 95% CI, 0.02-0.44) and WLWH born in Sweden (adjOR 0.1; 95% CI, 0.01-0.73), mostly because of decreased HPV16 and increased HPV35. WLWH from SSA were less likely to be covered by the 9-valent vaccine, mostly due to less HPV16 and more HPV35. This could have implications for HPV vaccines, currently not including HPV35, and for HPV-screening algorithms in women with origin from SSA.