Platelets mediate serological memory to neutralize viruses in vitro and in vivo

•Platelets contain virus-specific IgGs that potently diminish viral infection in vitro and in vivo.•Release of platelet IgG is more efficient at virus neutralization than equal amounts of plasma IgG. [Display omitted]

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Bibliographic Details
Published in:Blood advances 2020-08, Vol.4 (16), p.3971-3976
Main Authors: Schrottmaier, Waltraud C., Salzmann, Manuel, Badrnya, Sigrun, Mussbacher, Marion, Kral-Pointner, Julia B., Morava, Susanne, Pirabe, Anita, Brunnthaler, Laura, Yaiw, Koon C., Heber, Ulrike M., Pereyra, David, Andersen, Jan T., Bergthaler, Andreas, Söderberg-Nauclér, Cecilia, Karlsson, Mikael C.I., Assinger, Alice, Forsell, Mattias N.E.
Format: Article
Language:English
Subjects:
Blood Platelets
Medicin och hälsovetenskap
Stimulus Report
Viruses
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Description
Summary:•Platelets contain virus-specific IgGs that potently diminish viral infection in vitro and in vivo.•Release of platelet IgG is more efficient at virus neutralization than equal amounts of plasma IgG. [Display omitted]
ISSN:2473-9529
2473-9537
2473-9537
DOI:10.1182/bloodadvances.2020001786