Functionally distinct Purkinje cell types show temporal precision in encoding locomotion

Purkinje cells, the principal neurons of cerebellar computations, are believed to comprise a uniform neuronal population of cells, each with similar functional properties. Here, we show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and funct...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2020-07, Vol.117 (29), p.17330-17337
Main Authors: Chang, Weipang, Pedroni, Andrea, Hohendorf, Victoria, Giacomello, Stefania, Hibi, Masahiko, Köster, Reinhard W., Ampatzis, Konstantinos
Format: Article
Language:English
Subjects:
Biological Sciences
central pattern generator
Cerebellum
Circuits
Danio rerio
Heterogeneity
Locomotion
Medicin och hälsovetenskap
Purkinje cells
Synapses
Zebrafish
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Summary:Purkinje cells, the principal neurons of cerebellar computations, are believed to comprise a uniform neuronal population of cells, each with similar functional properties. Here, we show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types. Dual patch-clamp recordings showed that the cerebellar circuit contains all Purkinje cell types that cross-communicate extensively using chemical and electrical synapses. Further activation of spinal central pattern generators (CPGs) revealed unique phaselocked activity from each Purkinje cell type during the locomotor cycle. Thus, we show intricately organized Purkinje cell networks in the adult zebrafish cerebellum that encode the locomotion rhythm differentially, and we suggest that these organizational properties may also apply to other cerebellar functions
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.2005633117