Time to intra-arrest therapeutic hypothermia in out-of-hospital cardiac arrest patients and its association with neurologic outcome: a propensity matched sub-analysis of the PRINCESS trial

Purpose To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. Methods A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal ev...

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Bibliographic Details
Published in:Intensive care medicine 2020-07, Vol.46 (7), p.1361-1370
Main Authors: Awad, Akil, Taccone, Fabio Silvio, Jonsson, Martin, Forsberg, Sune, Hollenberg, Jacob, Truhlar, Anatolij, Ringh, Mattias, Abella, Benjamin S., Becker, Lance B., Vincent, Jean-Louis, Svensson, Leif, Nordberg, Per
Format: Article
Language:English
Subjects:
Ambulance services
Analysis
Anesthesiology
Cardiac arrest
Cardiac patients
Cardiopulmonary Resuscitation
Confidence intervals
Cooling
CPR
Critical Care Medicine
Emergency Medical Services
Emergency Medicine
Evaporative cooling
Heart
Heart attacks
Humans
Hypothermia
Hypothermia, Induced
Intensive
Intensive care
Medical colleges
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Odds Ratio
Original
Out-of-Hospital Cardiac Arrest - therapy
Pain Medicine
Patient outcomes
Patients
Pediatrics
Pneumology/Respiratory System
Population studies
Propensity Score
Recovering
Subgroups
Treatment Outcome
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Summary:Purpose To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. Methods A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arrest cooling initiated by emergency medical services or cooling started after hospital arrival. Early cooling (intervention) was defined as intra-arrest cooling initiated 
ISSN:0342-4642
1432-1238
1432-1238
DOI:10.1007/s00134-020-06024-3