Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake

Aims The body responds to exercise training by profound adaptations throughout the cardiorespiratory and muscular systems, which may result in improvements in maximal oxygen consumption (VO2peak) and mitochondrial capacity. By convenience, mitochondrial respiration is often measured at supra‐physiol...

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Bibliographic Details
Published in:Acta Physiologica 2020-07, Vol.229 (3), p.e13463-n/a
Main Authors: Larsen, Filip J., Schiffer, Tomas A., Zinner, Christoph, Willis, Sarah J., Morales‐Alamo, David, Calbet, Jose A.L., Boushel, Robert, Holmberg, Hans‐Christer
Format: Article
Language:English
Subjects:
Adaptation
Affinity
Arm
exercise
high intensity training
Interval training
maximal oxygen consumption
Medicin och hälsovetenskap
Medicin/Teknik
Medicine/Technology
Mitochondria
oxygen affinity
Oxygen consumption
Physical training
Physiology
sprint training
training
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Summary:Aims The body responds to exercise training by profound adaptations throughout the cardiorespiratory and muscular systems, which may result in improvements in maximal oxygen consumption (VO2peak) and mitochondrial capacity. By convenience, mitochondrial respiration is often measured at supra‐physiological oxygen levels, an approach that ignores any potential regulatory role of mitochondrial affinity for oxygen (p50mito) at physiological oxygen levels. Methods In this study, we examined the p50mito of mitochondria isolated from the Vastus lateralis and Triceps brachii in 12 healthy volunteers before and after a training intervention with seven sessions of sprint interval training using both leg cycling and arm cranking. The changes in p50mito were compared to changes in whole‐body VO2peak. Results We here show that p50mito is similar in isolated mitochondria from the Vastus (40 ± 3.8 Pa) compared to Triceps (39 ± 3.3) but decreases (mitochondrial oxygen affinity increases) after seven sessions of sprint interval training (to 26 ± 2.2 Pa in Vastus and 22 ± 2.7 Pa in Triceps, both P 
ISSN:1748-1708
1748-1716
1748-1716
DOI:10.1111/apha.13463