Association of post‐reperfusion syndrome and ischemia‐reperfusion injury with acute kidney injury after liver transplantation

Background Acute kidney injury (AKI) is frequently observed after orthotopic liver transplantation (OLT) even in patients with previously normal renal function. In this study, we investigated the impact of factors such graft steatosis, post‐reperfusion syndrome (PRS), and hepatic ischemia reperfusio...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2020-07, Vol.64 (6), p.742-750
Main Authors: Tokodai, Kazuaki, Lannsjö, Claudia, Kjaernet, Felicia, Romano, Antonio, Januszkiewicz, Anna, Ericzon, Bo‐Göran, Nowak, Greg
Format: Article
Language:English
Subjects:
Aspartate aminotransferase
Fatty liver
Grafting
Injuries
Ischemia
Kidney diseases
Kidney transplantation
Kidneys
Liver
Liver transplantation
Medicin och hälsovetenskap
Regression analysis
Renal function
Reperfusion
Risk analysis
Risk factors
Steatosis
Transplantation
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Summary:Background Acute kidney injury (AKI) is frequently observed after orthotopic liver transplantation (OLT) even in patients with previously normal renal function. In this study, we investigated the impact of factors such graft steatosis, post‐reperfusion syndrome (PRS), and hepatic ischemia reperfusion injury (HIRI) on the development of AKI after OLT in adult patients. Methods We retrospectively examined consecutive adult patients who underwent OLT at our institution between July 2011 and June 2017. AKI was diagnosed based on the criteria proposed by the International Kidney Disease Improving Global Outcomes (KDIGO) workgroup. Peak aspartate aminotransferase (AST) level within 72 hours after OLT was used as a surrogate marker for HIRI. Graft steatosis was diagnosed by histopathological examination using specimens biopsied intraoperatively at the end of transplantation procedure and categorized as
ISSN:0001-5172
1399-6576
1399-6576
DOI:10.1111/aas.13556