Microextraction approaches for bioanalytical applications: An overview

•MIPs and graphene tablets for drug extraction from biological fluids.•Microextraction by packed sorbent for bioanalytical applications.•Liquid-phase microextraction based on supported liquid membranes compatible with biological fluids.•High-performance materials as extractant phases.•3D printing in...

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Bibliographic Details
Published in:JOURNAL OF CHROMATOGRAPHY A 2020-04, Vol.1616, p.460790, Article 460790
Main Authors: Abdel-Rehim, Mohamed, Pedersen-Bjergaard, Stig, Abdel-Rehim, Abbi, Lucena, Rafael, Moein, Mohammad Mahdi, Cárdenas, Soledad, Miró, Manuel
Format: Article
Language:English
Subjects:
3-D printing
3D printers
3D printing
Bioanalysis
Bioanalytical applications
Bioanalytical methods
Chemical analysis
Extraction
Liquid phase micro extraction
Microextraction
Microextraction approaches
Nanomaterials
Nanostructured materials
Sample preparation
Toxicological analysis
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Summary:•MIPs and graphene tablets for drug extraction from biological fluids.•Microextraction by packed sorbent for bioanalytical applications.•Liquid-phase microextraction based on supported liquid membranes compatible with biological fluids.•High-performance materials as extractant phases.•3D printing in microextraction for bioanalytical applications. Biological samples are usually complex matrices due to the presence of proteins, salts and a variety of organic compounds with chemical properties similar to those of the target analytes. Therefore, sample preparation is often mandatory in order to isolate the analytes from troublesome matrices before instrumental analysis. Because the number of samples in drug development, doping analysis, forensic science, toxicological analysis, and preclinical and clinical assays is steadily increasing, novel high throughput sample preparation approaches are calling for. The key factors in this development are the miniaturization and the automation of the sample preparation approaches so as to cope with most of the twelve principles of green chemistry. In this review, recent trends in sample preparation and novel strategies will be discussed in detail with particular focus on sorptive and liquid-phase microextraction in bioanalysis. The actual applicability of selective sorbents is also considered. Additionally, the role of 3D printing in microextraction for bioanalytical methods will be pinpointed.
ISSN:0021-9673
1873-3778
DOI:10.1016/j.chroma.2019.460790