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Impact of CPAP treatment on leptin and adiponectin in adults with coronary artery disease and nonsleepy obstructive sleep apnoea in the RICCADSA trial
Increased leptin and decreased adiponectin levels are reported in coronary artery disease (CAD) as well as in obstructive sleep apnoea (OSA). Less is known regarding the impact of continuous positive airway pressure (CPAP) on these biomarkers. We aimed to determine variables associated with leptin a...
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| Published in: | Sleep medicine 2020-03, Vol.67, p.7-14 |
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| cites | cdi_FETCH-LOGICAL-c435t-f3b30c500a2f364689339466adc9684f24eb05006134756f15f389dee4ea099d3 |
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| container_title | Sleep medicine |
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| creator | Balcan, Baran Thunström, Erik Yucel-Lindberg, Tülay Lindberg, Kristin Ay, Pinar Peker, Yüksel |
| description | Increased leptin and decreased adiponectin levels are reported in coronary artery disease (CAD) as well as in obstructive sleep apnoea (OSA). Less is known regarding the impact of continuous positive airway pressure (CPAP) on these biomarkers. We aimed to determine variables associated with leptin and adiponectin in adults with CAD and nonsleepy OSA, and evaluate the effect of CPAP adjusted for confounding factors.
This was one of the secondary outcomes of the RICCADSA trial, conducted in Sweden between 2005 and 2013. From 244 revascularized CAD and OSA patients (apnoea–hypopnoea index >15/h) without excessive daytime sleepiness (Epworth Sleepiness Scale score |
| doi_str_mv | 10.1016/j.sleep.2019.10.016 |
| format | article |
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This was one of the secondary outcomes of the RICCADSA trial, conducted in Sweden between 2005 and 2013. From 244 revascularized CAD and OSA patients (apnoea–hypopnoea index >15/h) without excessive daytime sleepiness (Epworth Sleepiness Scale score <10), 196 with blood samples at baseline, after 3, and 12 months were included in the randomized controlled trial arm; of those, 98 were allocated to auto-titrating CPAP, and 98 to no-CPAP.
No significant changes in leptin and adiponectin levels were observed during follow-up, whereas Body-Mass-Index and waist circumference increased in both CPAP and no-CPAP groups with no significant between-group differences. Alterations in plasma leptin were determined by changes in waist circumference (beta coefficient 2.47; 95% confidence interval 0.77–4.40), whereas none of the analyzed parameters was predictive for changes in adiponectin levels. No association was found with CPAP adherence.
CPAP had no significant effect on leptin and adiponectin in this cohort of nonsleepy OSA patients. An increase in waist circumference predicted an increase in plasma levels of leptin after 12 months, suggesting that lifestyle modifications should be given priority in adults with CAD and OSA regardless of CPAP treatment.
•Increased leptin and decreased adiponectin levels are reported in coronary artery disease and obstructive sleep apnea.•Less is known regarding the impact of continuous positive airway pressure treatment (CPAP) on these biomarkers.•CPAP treatment for 12 months had no effect on circulating leptin and adiponection levels in the current cohort.•Alterations in leptin levels were determined by changes in waist circumference.•Lifestyle modifications should be considered in coronary artery disease and sleep apnea regardless of CPAP treatment.</description><identifier>ISSN: 1389-9457</identifier><identifier>EISSN: 1878-5506</identifier><identifier>DOI: 10.1016/j.sleep.2019.10.016</identifier><identifier>PMID: 31884309</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adiponectin ; Adiponectin - blood ; Aged ; association ; Biomarkers - metabolism ; c-reactive protein ; Cohort Studies ; Continuous Positive Airway Pressure ; Coronary Artery Disease - complications ; events ; Female ; ghrelin ; Humans ; insulin-resistance ; Leptin ; Leptin - blood ; Male ; Neurosciences ; Neurosciences & Neurology ; Neurovetenskaper ; obesity ; plasma ; Positive airway pressure ; rationale ; risk-factors ; Sleep Apnea, Obstructive - complications ; Sleep apnoea ; Sweden ; Weight gain</subject><ispartof>Sleep medicine, 2020-03, Vol.67, p.7-14</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-f3b30c500a2f364689339466adc9684f24eb05006134756f15f389dee4ea099d3</citedby><cites>FETCH-LOGICAL-c435t-f3b30c500a2f364689339466adc9684f24eb05006134756f15f389dee4ea099d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31884309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/293151$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:143238181$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Balcan, Baran</creatorcontrib><creatorcontrib>Thunström, Erik</creatorcontrib><creatorcontrib>Yucel-Lindberg, Tülay</creatorcontrib><creatorcontrib>Lindberg, Kristin</creatorcontrib><creatorcontrib>Ay, Pinar</creatorcontrib><creatorcontrib>Peker, Yüksel</creatorcontrib><title>Impact of CPAP treatment on leptin and adiponectin in adults with coronary artery disease and nonsleepy obstructive sleep apnoea in the RICCADSA trial</title><title>Sleep medicine</title><addtitle>Sleep Med</addtitle><description>Increased leptin and decreased adiponectin levels are reported in coronary artery disease (CAD) as well as in obstructive sleep apnoea (OSA). Less is known regarding the impact of continuous positive airway pressure (CPAP) on these biomarkers. We aimed to determine variables associated with leptin and adiponectin in adults with CAD and nonsleepy OSA, and evaluate the effect of CPAP adjusted for confounding factors.
This was one of the secondary outcomes of the RICCADSA trial, conducted in Sweden between 2005 and 2013. From 244 revascularized CAD and OSA patients (apnoea–hypopnoea index >15/h) without excessive daytime sleepiness (Epworth Sleepiness Scale score <10), 196 with blood samples at baseline, after 3, and 12 months were included in the randomized controlled trial arm; of those, 98 were allocated to auto-titrating CPAP, and 98 to no-CPAP.
No significant changes in leptin and adiponectin levels were observed during follow-up, whereas Body-Mass-Index and waist circumference increased in both CPAP and no-CPAP groups with no significant between-group differences. Alterations in plasma leptin were determined by changes in waist circumference (beta coefficient 2.47; 95% confidence interval 0.77–4.40), whereas none of the analyzed parameters was predictive for changes in adiponectin levels. No association was found with CPAP adherence.
CPAP had no significant effect on leptin and adiponectin in this cohort of nonsleepy OSA patients. An increase in waist circumference predicted an increase in plasma levels of leptin after 12 months, suggesting that lifestyle modifications should be given priority in adults with CAD and OSA regardless of CPAP treatment.
•Increased leptin and decreased adiponectin levels are reported in coronary artery disease and obstructive sleep apnea.•Less is known regarding the impact of continuous positive airway pressure treatment (CPAP) on these biomarkers.•CPAP treatment for 12 months had no effect on circulating leptin and adiponection levels in the current cohort.•Alterations in leptin levels were determined by changes in waist circumference.•Lifestyle modifications should be considered in coronary artery disease and sleep apnea regardless of CPAP treatment.</description><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Aged</subject><subject>association</subject><subject>Biomarkers - metabolism</subject><subject>c-reactive protein</subject><subject>Cohort Studies</subject><subject>Continuous Positive Airway Pressure</subject><subject>Coronary Artery Disease - complications</subject><subject>events</subject><subject>Female</subject><subject>ghrelin</subject><subject>Humans</subject><subject>insulin-resistance</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Neurovetenskaper</subject><subject>obesity</subject><subject>plasma</subject><subject>Positive airway pressure</subject><subject>rationale</subject><subject>risk-factors</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep apnoea</subject><subject>Sweden</subject><subject>Weight gain</subject><issn>1389-9457</issn><issn>1878-5506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kctu3CAUhq2qVZOmfYJKFctuPAWDsVl0MXJ6GSlSo17WCMNxwtQGF3CivEift3hmmmVWHD7-c-H8RfGW4A3BhH_Yb-IIMG8qTEQmm8yeFeekbdqyrjF_nmPailKwujkrXsW4x5g0pGUvizNK2pZRLM6Lv7tpVjohP6DuenuNUgCVJnCZODTCnKxDyhmkjJ29A73eV2SWMUV0b9Mt0j54p8IDUiFBPoyNoCIc0px3hyEfkO9jCkvOvwN0QEjNzoNaq6VbQN93Xbe9_LHNE1g1vi5eDGqM8OZ0XhS_Pn_62X0tr7592XXbq1IzWqdyoD3FusZYVQPljLeCUsE4V0YL3rKhYtDj_MwJZU3NB1IPeSUGgIHCQhh6UZTHuvEe5qWXc7BT_or0ysoT-p0jkKxhnNRP6m-WWWZ0s6z6SlBSk6x_f9TPwf9ZICY52ahhHJUDv0RZUUqyEZjTLKVHqQ4-xgDDY3GC5Wq43MvD4uRq-Aozy1nvTg2WfgLzmPPf4Sz4eBRAXuOdhSCjtuA0GBuyndJ4-2SDf4b8v1U</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Balcan, Baran</creator><creator>Thunström, Erik</creator><creator>Yucel-Lindberg, Tülay</creator><creator>Lindberg, Kristin</creator><creator>Ay, Pinar</creator><creator>Peker, Yüksel</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope></search><sort><creationdate>20200301</creationdate><title>Impact of CPAP treatment on leptin and adiponectin in adults with coronary artery disease and nonsleepy obstructive sleep apnoea in the RICCADSA trial</title><author>Balcan, Baran ; Thunström, Erik ; Yucel-Lindberg, Tülay ; Lindberg, Kristin ; Ay, Pinar ; Peker, Yüksel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-f3b30c500a2f364689339466adc9684f24eb05006134756f15f389dee4ea099d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Aged</topic><topic>association</topic><topic>Biomarkers - metabolism</topic><topic>c-reactive protein</topic><topic>Cohort Studies</topic><topic>Continuous Positive Airway Pressure</topic><topic>Coronary Artery Disease - complications</topic><topic>events</topic><topic>Female</topic><topic>ghrelin</topic><topic>Humans</topic><topic>insulin-resistance</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Neurovetenskaper</topic><topic>obesity</topic><topic>plasma</topic><topic>Positive airway pressure</topic><topic>rationale</topic><topic>risk-factors</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep apnoea</topic><topic>Sweden</topic><topic>Weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balcan, Baran</creatorcontrib><creatorcontrib>Thunström, Erik</creatorcontrib><creatorcontrib>Yucel-Lindberg, Tülay</creatorcontrib><creatorcontrib>Lindberg, Kristin</creatorcontrib><creatorcontrib>Ay, Pinar</creatorcontrib><creatorcontrib>Peker, Yüksel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>Sleep medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balcan, Baran</au><au>Thunström, Erik</au><au>Yucel-Lindberg, Tülay</au><au>Lindberg, Kristin</au><au>Ay, Pinar</au><au>Peker, Yüksel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of CPAP treatment on leptin and adiponectin in adults with coronary artery disease and nonsleepy obstructive sleep apnoea in the RICCADSA trial</atitle><jtitle>Sleep medicine</jtitle><addtitle>Sleep Med</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>67</volume><spage>7</spage><epage>14</epage><pages>7-14</pages><issn>1389-9457</issn><eissn>1878-5506</eissn><abstract>Increased leptin and decreased adiponectin levels are reported in coronary artery disease (CAD) as well as in obstructive sleep apnoea (OSA). Less is known regarding the impact of continuous positive airway pressure (CPAP) on these biomarkers. We aimed to determine variables associated with leptin and adiponectin in adults with CAD and nonsleepy OSA, and evaluate the effect of CPAP adjusted for confounding factors.
This was one of the secondary outcomes of the RICCADSA trial, conducted in Sweden between 2005 and 2013. From 244 revascularized CAD and OSA patients (apnoea–hypopnoea index >15/h) without excessive daytime sleepiness (Epworth Sleepiness Scale score <10), 196 with blood samples at baseline, after 3, and 12 months were included in the randomized controlled trial arm; of those, 98 were allocated to auto-titrating CPAP, and 98 to no-CPAP.
No significant changes in leptin and adiponectin levels were observed during follow-up, whereas Body-Mass-Index and waist circumference increased in both CPAP and no-CPAP groups with no significant between-group differences. Alterations in plasma leptin were determined by changes in waist circumference (beta coefficient 2.47; 95% confidence interval 0.77–4.40), whereas none of the analyzed parameters was predictive for changes in adiponectin levels. No association was found with CPAP adherence.
CPAP had no significant effect on leptin and adiponectin in this cohort of nonsleepy OSA patients. An increase in waist circumference predicted an increase in plasma levels of leptin after 12 months, suggesting that lifestyle modifications should be given priority in adults with CAD and OSA regardless of CPAP treatment.
•Increased leptin and decreased adiponectin levels are reported in coronary artery disease and obstructive sleep apnea.•Less is known regarding the impact of continuous positive airway pressure treatment (CPAP) on these biomarkers.•CPAP treatment for 12 months had no effect on circulating leptin and adiponection levels in the current cohort.•Alterations in leptin levels were determined by changes in waist circumference.•Lifestyle modifications should be considered in coronary artery disease and sleep apnea regardless of CPAP treatment.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31884309</pmid><doi>10.1016/j.sleep.2019.10.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Adiponectin Adiponectin - blood Aged association Biomarkers - metabolism c-reactive protein Cohort Studies Continuous Positive Airway Pressure Coronary Artery Disease - complications events Female ghrelin Humans insulin-resistance Leptin Leptin - blood Male Neurosciences Neurosciences & Neurology Neurovetenskaper obesity plasma Positive airway pressure rationale risk-factors Sleep Apnea, Obstructive - complications Sleep apnoea Sweden Weight gain |
| title | Impact of CPAP treatment on leptin and adiponectin in adults with coronary artery disease and nonsleepy obstructive sleep apnoea in the RICCADSA trial |
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