Circulatory factors associated with function and prognosis in patients with severe heart failure

Background Multiple circulatory factors are increased in heart failure (HF). Many have been linked to cardiac and/or skeletal muscle tissue processes, which in turn might influence physical activity and/or capacity during HF. This study aimed to provide a better understanding of the mechanisms linki...

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Bibliographic Details
Published in:Clinical research in cardiology 2020-06, Vol.109 (6), p.655-672
Main Authors: Rullman, Eric, Melin, Michael, Mandić, Mirko, Gonon, Adrian, Fernandez-Gonzalo, Rodrigo, Gustafsson, Thomas
Format: Article
Language:English
Subjects:
Accelerometers
Aged
Angiogenesis
Biomarkers
Biomarkers - blood
Cardiology
Cell adhesion
Cell adhesion & migration
Congestive heart failure
Discriminant analysis
Echocardiography
Extracellular matrix
Female
Follow-Up Studies
Heart
Heart failure
Heart Failure - diagnosis
Heart Failure - metabolism
Heart Failure - physiopathology
Hemodynamics
Humans
Immunoassay
Male
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Middle Aged
Muscles
Original Paper
Oxygen - metabolism
Oxygen Consumption
Oxygen uptake
Pathogenesis
Physical activity
Principal components analysis
Prognosis
Prospective Studies
Severity of Illness Index
Skeletal muscle
Stroke Volume - physiology
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Summary:Background Multiple circulatory factors are increased in heart failure (HF). Many have been linked to cardiac and/or skeletal muscle tissue processes, which in turn might influence physical activity and/or capacity during HF. This study aimed to provide a better understanding of the mechanisms linking HF with the loss of peripheral function. Methods and results Physical capacity measured by maximum oxygen uptake, myocardial function (measured by echocardiography), physical activity (measured by accelerometry), and mortality data was collected for patients with severe symptomatic heart failure an ejection fraction 
ISSN:1861-0684
1861-0692
1861-0692
DOI:10.1007/s00392-019-01554-3