Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

Objective To evaluate enzymatic total serum bile acid quantification as a monitoring strategy for women with intrahepatic cholestasis of pregnancy (ICP) treated with ursodeoxycholic acid (UDCA). Design Cohort. Setting One UK university hospital. Population 29 ICP cases treated with UDCA. Methods Ser...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2019-12, Vol.126 (13), p.1633-1640
Main Authors: Manna, LB, Ovadia, C, Lövgren‐Sandblom, A, Chambers, J, Begum, S, Seed, P, Walker, I, Chappell, LC, Marschall, H‐U, Williamson, C
Format: Article
Language:English
Subjects:
Acids
Adult
Bile
Bile acid assay
Bile acids
Bile Acids and Salts - blood
Chenodeoxycholic acid
Cholagogues and Choleretics - therapeutic use
Cholestasis
Cholestasis, Intrahepatic - blood
Cholestasis, Intrahepatic - drug therapy
Cholic acid
Cohort analysis
Female
fetal-death
Gallbladder diseases
Gestation
Humans
Liquid chromatography
Liver Function Tests
management
Mass spectroscopy
Maternal Medicine
Medicin och hälsovetenskap
obstetric cholestasis
Obstetrics & Gynecology
Obstetrics, Gynecology and Reproductive Medicine
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - drug therapy
Prospective Studies
Reproduktionsmedicin och gynekologi
Treatment Outcome
Ursodeoxycholic acid
Ursodeoxycholic Acid - therapeutic use
Womens health
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Summary:Objective To evaluate enzymatic total serum bile acid quantification as a monitoring strategy for women with intrahepatic cholestasis of pregnancy (ICP) treated with ursodeoxycholic acid (UDCA). Design Cohort. Setting One UK university hospital. Population 29 ICP cases treated with UDCA. Methods Serial samples were collected prospectively throughout gestation. Total serum bile acids were measured enzymatically and individual bile acids by high‐performance liquid chromatography‐tandem mass spectrometry. Data were log‐transformed and analysed with random effects generalised least square regression. Main outcome measures The relationship between enzymatic total bile acid measurements and individual bile acid concentrations after UDCA treatment. Results In untreated women, cholic acid was the principal bile acid (51%) and UDCA concentrations were
ISSN:1470-0328
1471-0528
1471-0528
DOI:10.1111/1471-0528.15926