The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases

• Published in: Clinical oral investigations 2020-05, Vol.24 (5), p.1837-1844
• Main Authors: Teixeira, Mayla K. S., Lira-Junior, Ronaldo, Lourenço, Eduardo José Veras, Telles, Daniel Moraes, Boström, Elisabeth A., Figueredo, Carlos Marcelo, Bostanci, Nagihan
• Format: Article
• Language: English
• Subjects: Dental implants; Dentistry; Enzyme-linked immunosorbent assay; Gingivitis; Gum disease; Inflammation; Medicin och hälsovetenskap; Medicine; Mucositis; Neutrophil collagenase; Original Article; Periodontitis; Saliva; Tissue inhibitor of metalloproteinase 1; Transplants & implants
• ISSN: 1432-6981; 1436-3771; 1436-3771
• DOI: 10.1007/s00784-019-03047-z

Objectives The aim of this study is to investigate the expression of sTREM-1 and its ligand PGLYRP1, as well as the expression of MMP-8 and its inhibitor TIMP-1, in peri-implant diseases. As a secondary aim, we analyzed the influence of the concomitant existence of periodontitis in the expression of these biomarkers. Materials and methods This study included 77 patients (29 males and 48 females; mean age 55.0 ± 11.5), 18 having gingivitis, 16 having periodontitis, 20 having mucositis, and 23 having peri-implantitis. Patients were clinically examined, and unstimulated whole saliva was collected. sTREM-1, PGLYRP1, MMP-8, TIMP-1, and MMP-8/TIMP1 ratio were determined by ELISA. Results The periodontitis group presented higher probing depth (PD) mean, and higher clinical attachment loss, compared with the other groups. The peri-implantitis group presented higher PD mean in implants compared to the mucositis group. Patients with PD ≥ 6 mm showed significantly higher levels of PGLYRP1, MMP-8, and MMP-8/TIMP-1 ratio than patients with PD