Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men

Purpose Fatty acid composition in blood and adipose tissue (AT) is a useful biomarker of dietary fat quality. However, circulating saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) have been proposed to also reflect carbohydrate-induced de novo lipogenesis (DNL) and stearoyl-CoA des...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nutrition 2020-08, Vol.59 (5), p.2089-2097
Main Authors: Alsharari, Zayed D., Leander, Karin, Sjögren, Per, Carlsson, Axel, Cederholm, Tommy, de Faire, Ulf, Hellenius, Mai-Lis, Marklund, Matti, Risérus, Ulf
Format: Article
Language:English
Subjects:
Adipose tissue
Alcohol intake
Alcoholic beverages
Beverages
Carbohydrate intake
Carbohydrates
Chemistry
Chemistry and Materials Science
De novo lipogenesis
Desaturase
Disaccharides
Fatty acid composition
Fatty acids
Food intake
Gas chromatography
Lipogenesis
Mens health
Nutrition
Original Contribution
Palmitic acid
Phospholipids
Saturated fatty acids
Stearoyl-Co A desaturase (SCD)
Stearoyl-CoA desaturase
Sugar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Fatty acid composition in blood and adipose tissue (AT) is a useful biomarker of dietary fat quality. However, circulating saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) have been proposed to also reflect carbohydrate-induced de novo lipogenesis (DNL) and stearoyl-CoA desaturase (SCD) activity. We aimed to test the hypothesis that high carbohydrate intake is related to SFA and MUFA in serum or AT in a Swedish population. Methods Fatty acid composition was measured in serum phospholipids (PL) and AT by gas chromatography in 63-year-old men ( n  = 299). Carbohydrate and alcohol intake was assessed (validated 7-day food records) in relation to total SFA, 16:0 (palmitate), 16:1 (palmitoleate), and estimated SCD activity (16:1n-7/16:0-ratio) in serum PL and in AT, respectively. Results Total carbohydrate intake was inversely associated with 16:0 in PL ( P  = 0.005), independently of BMI. Disaccharides were non-linearly (restricted cubic splines) and weakly associated with 16:1 and SCD activity in PL (nonlinear trend, P  ≤ 0.02) but not AT. Carbohydrate intake and SCD expression were not associated ( P  ≥ 0.08, n  = 81). Alcohol intake was, however, linearly associated with 16:0 in PL ( P  
ISSN:1436-6207
1436-6215
1436-6215
DOI:10.1007/s00394-019-02058-6