Radiation-induced Vascular Damage and the Impact on the Treatment Outcome of Stereotactic Body Radiotherapy

The aim of this study was to investigate radiation-induced tumour vascular damage and its impact thereof on the outcome of stereotactic body radiotherapy (SBRT). Vessel densities in animal tumours before and after a single dose of 20 Gy were quantified and used as input for simulations of three-dime...

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Bibliographic Details
Published in:Anticancer research 2019-06, Vol.39 (6), p.2721-2727
Main Authors: Lindblom, Emely Kjellsson, Hui, Susanta, Brooks, Jamison, Dasu, Alexandru, Kujawski, Maciej, Toma-Dasu, Iuliana
Format: Article
Language:English
Subjects:
Animals
Background radiation
Blood vessels
Blood Vessels - diagnostic imaging
Blood Vessels - injuries
Blood Vessels - radiation effects
Breast Neoplasms - blood supply
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - radiotherapy
Cell Hypoxia
Cell Line, Tumor
Collapse
Computer simulation
Dose Fractionation, Radiation
Female
Humans
Hypoxia
Impact damage
Medicin och hälsovetenskap
Mice
Microscopy, Fluorescence, Multiphoton
Models, Biological
Neoplasm Transplantation
Oxygenation
Radiation
Radiation damage
Radiation effects
Radiation therapy
radiation-induced vascular damage
Radiosurgery - adverse effects
SBRT
stereotactic body radiotherapy
TCP
Three dimensional models
Treatment Outcome
Tumors
tumour control probability
tumour oxygenation
vascular damage
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Summary:The aim of this study was to investigate radiation-induced tumour vascular damage and its impact thereof on the outcome of stereotactic body radiotherapy (SBRT). Vessel densities in animal tumours before and after a single dose of 20 Gy were quantified and used as input for simulations of three-dimensional tumours with heterogeneous oxygenation. SBRT treatments of the modelled tumours in 1-8 fractions were simulated. The impact of vessel collapse on the outcome of SBRT was investigated by calculating tumour control probability (TCP) and the dose required to obtain a TCP of 50% (D ). A radiation-induced increase of acute hypoxia in tumours during SBRT treatment could be simulated based on the experimental data. The D values for these tumours were higher than for the simulated tumours without vessel collapse. The vascular changes after high doses of radiation could compromise the outcome of SBRT by increasing tumour hypoxia.
ISSN:0250-7005
1791-7530
1791-7530
DOI:10.21873/anticanres.13398