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Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma
Aims Histological assessment of stromal maturity is a potential prognostic factor in colorectal cancer, but its applicability in gastric adenocarcinoma is completely unknown. The aim of this study was to evaluate the feasibility and prognostic significance of assessing stromal maturity in gastric ad...
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| Published in: | Histopathology 2019-12, Vol.75 (6), p.882-889 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4764-fb875667fda1a96e217e4fde51323d2b58eb6caf56d0344f2fc5b4e4ded92ec53 |
| container_end_page | 889 |
| container_issue | 6 |
| container_start_page | 882 |
| container_title | Histopathology |
| container_volume | 75 |
| creator | Kemi, Niko A Eskuri, Maarit Pohjanen, Vesa‐Matti Karttunen, Tuomo J Kauppila, Joonas H |
| description | Aims
Histological assessment of stromal maturity is a potential prognostic factor in colorectal cancer, but its applicability in gastric adenocarcinoma is completely unknown. The aim of this study was to evaluate the feasibility and prognostic significance of assessing stromal maturity in gastric adenocarcinoma.
Methods and results
This study was conducted retrospectively in a cohort of 583 gastric adenocarcinoma patients treated surgically in Oulu University Hospital, Finland between 1983 and 2016. The original diagnostic slides were used for assessment of stromal maturity. Patients were divided into mature stroma and immature stroma groups, and stromal maturity was analysed in relation to 5‐year and overall survival (OS). The primary outcome of the study was 5‐year survival, and the secondary outcome was OS. The kappa‐coefficient for interobserver agreement was 0.609. Patients with immature stroma had worse 5‐year survival compared to patients with mature stroma [adjusted hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.06–1.64]. Stromal maturity was significantly associated with 5‐year survival in intestinal‐type subgroup (adjusted HR = 0.63, 95% CI = 1.20–2.21), but not in the diffuse‐type subgroup (adjusted HR = 1.21, 95% CI = 0.87–1.70).
Conclusions
Stromal maturity is an independent prognostic factor in gastric adenocarcinoma, and it can be analysed with moderate reproducibility. |
| doi_str_mv | 10.1111/his.13934 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_479272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2317565481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4764-fb875667fda1a96e217e4fde51323d2b58eb6caf56d0344f2fc5b4e4ded92ec53</originalsourceid><addsrcrecordid>eNp1kUtv1DAUhS0EokNhwR9AkdjQRVo_81iiqnQqVWIBrC3Hvh5ckniwHVXz77k00yIh1Rtb19859r2HkPeMnjNcFz9DPmeiF_IF2TDRqJor1b8kGypoX1PWtCfkTc53lLJWcP6anAiGJ9HJDYnbkEsc4y5YM1YmZ8h5grlU0Ve5pDhhdTJlSaEc8Loy1T7F3RxzCbbyxpaYqjBXeUkPDuOhKglMAVftDOoRMg7maE2yYUa3t-SVN2OGd8f9lPz4cvX9clvffr2-ufx8W1vZNrL2Q9eqpmm9M8z0DXDWgvQOFBNcOD6oDobGGq8aR4WUnnurBgnSges5WCVOSb365nvYL4PepzCZdNDRBH0s_cITaNn2vOXI98_y2LH7J3oUMskpjrDpUftp1SL4e4Fc9BSyhXE0M8Qlay6owmd62iH68T_0Li5pxkkgxbBlJTuG1NlK2RRzTuCfvsOo_pu4xsT1Q-LIfjg6LsME7ol8jBiBixW4DyMcnnfS25tvq-Uf_Ua46Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2317565481</pqid></control><display><type>article</type><title>Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma</title><source>Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)</source><creator>Kemi, Niko A ; Eskuri, Maarit ; Pohjanen, Vesa‐Matti ; Karttunen, Tuomo J ; Kauppila, Joonas H</creator><creatorcontrib>Kemi, Niko A ; Eskuri, Maarit ; Pohjanen, Vesa‐Matti ; Karttunen, Tuomo J ; Kauppila, Joonas H</creatorcontrib><description>Aims
Histological assessment of stromal maturity is a potential prognostic factor in colorectal cancer, but its applicability in gastric adenocarcinoma is completely unknown. The aim of this study was to evaluate the feasibility and prognostic significance of assessing stromal maturity in gastric adenocarcinoma.
Methods and results
This study was conducted retrospectively in a cohort of 583 gastric adenocarcinoma patients treated surgically in Oulu University Hospital, Finland between 1983 and 2016. The original diagnostic slides were used for assessment of stromal maturity. Patients were divided into mature stroma and immature stroma groups, and stromal maturity was analysed in relation to 5‐year and overall survival (OS). The primary outcome of the study was 5‐year survival, and the secondary outcome was OS. The kappa‐coefficient for interobserver agreement was 0.609. Patients with immature stroma had worse 5‐year survival compared to patients with mature stroma [adjusted hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.06–1.64]. Stromal maturity was significantly associated with 5‐year survival in intestinal‐type subgroup (adjusted HR = 0.63, 95% CI = 1.20–2.21), but not in the diffuse‐type subgroup (adjusted HR = 1.21, 95% CI = 0.87–1.70).
Conclusions
Stromal maturity is an independent prognostic factor in gastric adenocarcinoma, and it can be analysed with moderate reproducibility.</description><identifier>ISSN: 0309-0167</identifier><identifier>ISSN: 1365-2559</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.13934</identifier><identifier>PMID: 31173384</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Cohort Studies ; collagen ; Colorectal carcinoma ; Feasibility Studies ; Female ; Finland ; gastric cancer ; Humans ; Intestine ; Kaplan-Meier Estimate ; Male ; Maturity ; Medicin och hälsovetenskap ; Prognosis ; Proportional Hazards Models ; Reproducibility of Results ; Retrospective Studies ; Stomach - pathology ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Stroma ; Stromal Cells - pathology ; Survival</subject><ispartof>Histopathology, 2019-12, Vol.75 (6), p.882-889</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4764-fb875667fda1a96e217e4fde51323d2b58eb6caf56d0344f2fc5b4e4ded92ec53</citedby><cites>FETCH-LOGICAL-c4764-fb875667fda1a96e217e4fde51323d2b58eb6caf56d0344f2fc5b4e4ded92ec53</cites><orcidid>0000-0002-8843-7957 ; 0000-0001-6012-0010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31173384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:142038469$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kemi, Niko A</creatorcontrib><creatorcontrib>Eskuri, Maarit</creatorcontrib><creatorcontrib>Pohjanen, Vesa‐Matti</creatorcontrib><creatorcontrib>Karttunen, Tuomo J</creatorcontrib><creatorcontrib>Kauppila, Joonas H</creatorcontrib><title>Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Histological assessment of stromal maturity is a potential prognostic factor in colorectal cancer, but its applicability in gastric adenocarcinoma is completely unknown. The aim of this study was to evaluate the feasibility and prognostic significance of assessing stromal maturity in gastric adenocarcinoma.
Methods and results
This study was conducted retrospectively in a cohort of 583 gastric adenocarcinoma patients treated surgically in Oulu University Hospital, Finland between 1983 and 2016. The original diagnostic slides were used for assessment of stromal maturity. Patients were divided into mature stroma and immature stroma groups, and stromal maturity was analysed in relation to 5‐year and overall survival (OS). The primary outcome of the study was 5‐year survival, and the secondary outcome was OS. The kappa‐coefficient for interobserver agreement was 0.609. Patients with immature stroma had worse 5‐year survival compared to patients with mature stroma [adjusted hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.06–1.64]. Stromal maturity was significantly associated with 5‐year survival in intestinal‐type subgroup (adjusted HR = 0.63, 95% CI = 1.20–2.21), but not in the diffuse‐type subgroup (adjusted HR = 1.21, 95% CI = 0.87–1.70).
Conclusions
Stromal maturity is an independent prognostic factor in gastric adenocarcinoma, and it can be analysed with moderate reproducibility.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Cohort Studies</subject><subject>collagen</subject><subject>Colorectal carcinoma</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Finland</subject><subject>gastric cancer</subject><subject>Humans</subject><subject>Intestine</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Maturity</subject><subject>Medicin och hälsovetenskap</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Stroma</subject><subject>Stromal Cells - pathology</subject><subject>Survival</subject><issn>0309-0167</issn><issn>1365-2559</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kUtv1DAUhS0EokNhwR9AkdjQRVo_81iiqnQqVWIBrC3Hvh5ckniwHVXz77k00yIh1Rtb19859r2HkPeMnjNcFz9DPmeiF_IF2TDRqJor1b8kGypoX1PWtCfkTc53lLJWcP6anAiGJ9HJDYnbkEsc4y5YM1YmZ8h5grlU0Ve5pDhhdTJlSaEc8Loy1T7F3RxzCbbyxpaYqjBXeUkPDuOhKglMAVftDOoRMg7maE2yYUa3t-SVN2OGd8f9lPz4cvX9clvffr2-ufx8W1vZNrL2Q9eqpmm9M8z0DXDWgvQOFBNcOD6oDobGGq8aR4WUnnurBgnSges5WCVOSb365nvYL4PepzCZdNDRBH0s_cITaNn2vOXI98_y2LH7J3oUMskpjrDpUftp1SL4e4Fc9BSyhXE0M8Qlay6owmd62iH68T_0Li5pxkkgxbBlJTuG1NlK2RRzTuCfvsOo_pu4xsT1Q-LIfjg6LsME7ol8jBiBixW4DyMcnnfS25tvq-Uf_Ua46Q</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Kemi, Niko A</creator><creator>Eskuri, Maarit</creator><creator>Pohjanen, Vesa‐Matti</creator><creator>Karttunen, Tuomo J</creator><creator>Kauppila, Joonas H</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-8843-7957</orcidid><orcidid>https://orcid.org/0000-0001-6012-0010</orcidid></search><sort><creationdate>201912</creationdate><title>Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma</title><author>Kemi, Niko A ; Eskuri, Maarit ; Pohjanen, Vesa‐Matti ; Karttunen, Tuomo J ; Kauppila, Joonas H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4764-fb875667fda1a96e217e4fde51323d2b58eb6caf56d0344f2fc5b4e4ded92ec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Cohort Studies</topic><topic>collagen</topic><topic>Colorectal carcinoma</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Finland</topic><topic>gastric cancer</topic><topic>Humans</topic><topic>Intestine</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Maturity</topic><topic>Medicin och hälsovetenskap</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Stroma</topic><topic>Stromal Cells - pathology</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kemi, Niko A</creatorcontrib><creatorcontrib>Eskuri, Maarit</creatorcontrib><creatorcontrib>Pohjanen, Vesa‐Matti</creatorcontrib><creatorcontrib>Karttunen, Tuomo J</creatorcontrib><creatorcontrib>Kauppila, Joonas H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kemi, Niko A</au><au>Eskuri, Maarit</au><au>Pohjanen, Vesa‐Matti</au><au>Karttunen, Tuomo J</au><au>Kauppila, Joonas H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2019-12</date><risdate>2019</risdate><volume>75</volume><issue>6</issue><spage>882</spage><epage>889</epage><pages>882-889</pages><issn>0309-0167</issn><issn>1365-2559</issn><eissn>1365-2559</eissn><abstract>Aims
Histological assessment of stromal maturity is a potential prognostic factor in colorectal cancer, but its applicability in gastric adenocarcinoma is completely unknown. The aim of this study was to evaluate the feasibility and prognostic significance of assessing stromal maturity in gastric adenocarcinoma.
Methods and results
This study was conducted retrospectively in a cohort of 583 gastric adenocarcinoma patients treated surgically in Oulu University Hospital, Finland between 1983 and 2016. The original diagnostic slides were used for assessment of stromal maturity. Patients were divided into mature stroma and immature stroma groups, and stromal maturity was analysed in relation to 5‐year and overall survival (OS). The primary outcome of the study was 5‐year survival, and the secondary outcome was OS. The kappa‐coefficient for interobserver agreement was 0.609. Patients with immature stroma had worse 5‐year survival compared to patients with mature stroma [adjusted hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.06–1.64]. Stromal maturity was significantly associated with 5‐year survival in intestinal‐type subgroup (adjusted HR = 0.63, 95% CI = 1.20–2.21), but not in the diffuse‐type subgroup (adjusted HR = 1.21, 95% CI = 0.87–1.70).
Conclusions
Stromal maturity is an independent prognostic factor in gastric adenocarcinoma, and it can be analysed with moderate reproducibility.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31173384</pmid><doi>10.1111/his.13934</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8843-7957</orcidid><orcidid>https://orcid.org/0000-0001-6012-0010</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Histopathology, 2019-12, Vol.75 (6), p.882-889 |
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| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adenocarcinoma - surgery Cohort Studies collagen Colorectal carcinoma Feasibility Studies Female Finland gastric cancer Humans Intestine Kaplan-Meier Estimate Male Maturity Medicin och hälsovetenskap Prognosis Proportional Hazards Models Reproducibility of Results Retrospective Studies Stomach - pathology Stomach Neoplasms - diagnosis Stomach Neoplasms - pathology Stomach Neoplasms - surgery Stroma Stromal Cells - pathology Survival |
| title | Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma |
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