Advances in therapeutic applications of extracellular vesicles

Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological an...

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Bibliographic Details
Published in:Science translational medicine 2019-05, Vol.11 (492), p.1
Main Authors: Wiklander, Oscar P B, Brennan, Meadhbh Á, Lötvall, Jan, Breakefield, Xandra O, El Andaloussi, Samir
Format: Article
Language:English
Subjects:
Cell and Molecular Biology
Cell interactions
Cell signaling
Cell- och molekylärbiologi
Cellular Biology
dendritic cells
drug-delivery
exosome-mediated delivery
Extracellular vesicles
gene delivery
immune-responses
Immunomodulation
in-vitro
Life Sciences
Medicin och hälsovetenskap
Membrane vesicles
mesenchymal stromal cells
neutralizing antibodies
Stem cells
Therapeutic applications
transferrin receptor
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Summary:Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.
ISSN:1946-6234
1946-6242
1946-6242
1946-3242
DOI:10.1126/scitranslmed.aav8521