Retinal layer thickness in preclinical Alzheimer's disease

• Published in: Acta ophthalmologica (Oxford, England) England), 2019-12, Vol.97 (8), p.798-804
• Main Authors: Kreeke, Jacoba A., Nguyen, Hoang‐Ton, Haan, Jurre, Konijnenberg, Elles, Tomassen, Jori, Braber, Anouk, Kate, Mara, Collij, Lyduine, Yaqub, Maqsood, Berckel, Bart, Lammertsma, Adriaan A., Boomsma, Dorret I., Tan, Hendra Stevie, Verbraak, Frank D., Visser, Pieter Jelle
• Format: Article
• Language: English
• Subjects: Aged; Alzheimer Disease - diagnosis; Alzheimer's disease; Biomarkers; Brain - diagnostic imaging; Cortex; Female; Humans; Macula Lutea - pathology; Magnetic Resonance Imaging; Male; Medicin och hälsovetenskap; Middle Aged; Neurodegenerative diseases; OCT; ocular biomarkers; Original; Positron emission tomography; preclinical Alzheimer's disease; Retina; Retinal Ganglion Cells - pathology; Statistical analysis; Tomography, Optical Coherence - methods; twins
• ISSN: 1755-375X; 1755-3768; 1755-3768
• DOI: 10.1111/aos.14121

Purpose There is urgent need for non‐invasive diagnostic biomarkers in the preclinical phase of Alzheimer's Disease (AD). Several studies suggest that retinal thickness is reduced in AD. Here, we aim to test the diagnostic value of retinal thickness in preclinical AD, as defined by cognitively normal individuals with amyloid pathology on PET. Methods One hundred and sixty five cognitively healthy monozygotic twins aged ≥ 60 were included from the Netherlands Twin Register taking part in the European Medical Information Framework for Alzheimer's Disease PreclinAD study. Participants underwent [18F] flutemetamol PET that was visually rated for presence or absence of cortical amyloid beta (Aβ). Binding potential (BPND) was calculated as continuous measure for Aβ. Spectral Domain OCT was used to asses total and individual inner retinal layer thickness in the macular region (ETDRS circles) as well as peripapillary retinal nerve fibre layer (pRNFL) thickness. Differences between Aβ+ and Aβ− individuals and associations between BPND and retinal thickness were analyzed. Results No differences were found in retinal layer thickness in the macula or pRNFL between Aβ+ and Aβ− individuals. A positive associations between BPND and macular total retinal thickness was observed in the inner ring (p = 0.018), but this was not statistically significant after correction for multiple testing (p = 0.144). Brain/eye parameters had moderate to high intra‐twin correlations (p