Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease

Motor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the pr...

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Bibliographic Details
Published in:Scientific reports 2019-02, Vol.9 (1), p.2604-2604, Article 2604
Main Authors: Vinding, Mikkel C., Tsitsi, Panagiota, Piitulainen, Harri, Waldthaler, Josefine, Jousmäki, Veikko, Ingvar, Martin, Svenningsson, Per, Lundqvist, Daniel
Format: Article
Language:English
Subjects:
631/378/2620/2618
631/378/2632/1663
692/617/375/1718
Cortex
Feedback
Humanities and Social Sciences
Levodopa
Magnetoencephalography
Movement disorders
multidisciplinary
Neurodegenerative diseases
Oscillations
Parkinson's disease
Proprioception
Science
Science (multidisciplinary)
Sensory integration
Sensory neurons
Synchronization
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Summary:Motor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8–30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical processing of proprioceptive afference in PD.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-39204-3