The effect of different sources of fish and camelina sativa oil on immune cell and adipose tissue mRNA expression in subjects with abnormal fasting glucose metabolism: a randomized controlled trial

Background/Objectives Molecular mechanisms linking fish and vegetable oil intakes to their healthy metabolic effects may involve attenuation of inflammation. Our primary aim was to examine in a randomized controlled setting whether diets enriched in fatty fish (FF), lean fish (LF) or ALA-rich cameli...

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Bibliographic Details
Published in:Nutrition & diabetes 2019-01, Vol.9 (1), p.1-1, Article 1
Main Authors: de Mello, Vanessa D., Dahlman, Ingrid, Lankinen, Maria, Kurl, Sudhir, Pitkänen, Leena, Laaksonen, David E., Schwab, Ursula S., Erkkilä, Arja T.
Format: Article
Language:English
Subjects:
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Adipose Tissue - metabolism
Adult
Aged
Animals
Brassicaceae
Clinical Nutrition
Diabetes
Diet
Epidemiology
Fatty acids
Female
Fish oils
Fish Oils - administration & dosage
Fishes
Gene Expression
Humans
Inflammation
Inflammation - blood
Inflammation - diet therapy
Insulin Resistance
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - metabolism
Internal Medicine
Leukocytes, Mononuclear - metabolism
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Middle Aged
Plant Oils - administration & dosage
RNA, Messenger - analysis
Treatment Outcome
Vegetable oils
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Summary:Background/Objectives Molecular mechanisms linking fish and vegetable oil intakes to their healthy metabolic effects may involve attenuation of inflammation. Our primary aim was to examine in a randomized controlled setting whether diets enriched in fatty fish (FF), lean fish (LF) or ALA-rich camelina sativa oil (CSO) differ in their effects on the mRNA expression response of selected inflammation-related genes in peripheral blood mononuclear cells (PBMCs) and subcutaneous adipose tissue (SAT) in subjects with impaired fasting glucose. Subjects/Methods Samples from 72 participants randomized to one of the following 12-week intervention groups, FF ( n  = 19), LF ( n  = 19), CSO ( n  = 17) or a control group ( n  = 17), were available for the PBMC study. For SAT, 39 samples ( n  = 8, n  = 10, n  = 9, n  = 12, respectively) were available. The mRNA expression was measured at baseline and 12 weeks by TaqMan® Low Density Array. Results In PBMCs, LF decreased ICAM1 mRNA expression ( P  
ISSN:2044-4052
2044-4052
DOI:10.1038/s41387-018-0069-2