Serum potassium and clinical outcomes in heart failure patients: results of risk calculations in 21 334 patients in the UK

Aims At present, the clinical burden of hypokalaemia and hyperkalaemia among European heart failure patients, and relationships between serum potassium and adverse clinical outcomes in this population, is not well characterized. The aim of this study was to investigate associations between mortality...

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Bibliographic Details
Published in:ESC Heart Failure 2019-04, Vol.6 (2), p.280-290
Main Authors: Linde, Cecilia, Qin, Lei, Bakhai, Ameet, Furuland, Hans, Evans, Marc, Ayoubkhani, Daniel, Palaka, Eirini, Bennett, Hayley, McEwan, Phil
Format: Article
Language:English
Subjects:
Aged
Angiotensin Receptor Antagonists - therapeutic use
Biomarkers - blood
Cardiac arrhythmia
Classification
Clinical outcomes
Demographics
Female
Follow-Up Studies
Heart failure
Heart Failure - blood
Heart Failure - complications
Heart Failure - drug therapy
Humans
Hyperkalaemia
Hyperkalemia - blood
Hyperkalemia - epidemiology
Hyperkalemia - etiology
Hypokalemia - blood
Hypokalemia - epidemiology
Hypokalemia - etiology
Incidence
Kidney diseases
Major adverse cardiac event
Male
Mortality
Original
Original s
Patients
Potassium
Potassium - blood
Primary care
Prognosis
Renin-Angiotensin System - physiology
Renin-angiotensin-aldosterone system inhibitor therapy
Retrospective Studies
Risk Assessment
Serum potassium
Survival Rate - trends
United Kingdom - epidemiology
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Summary:Aims At present, the clinical burden of hypokalaemia and hyperkalaemia among European heart failure patients, and relationships between serum potassium and adverse clinical outcomes in this population, is not well characterized. The aim of this study was to investigate associations between mortality, major adverse cardiac events, and renin–angiotensin–aldosterone system inhibitor (RAASi) discontinuation across serum potassium levels, in a UK cohort of incident heart failure patients. Methods and results This was a retrospective observational cohort study of newly diagnosed heart failure patients listed in the Clinical Practice Research Datalink, with a first record of heart failure (index date) between 2006 and 2015. Hypokalaemia and hyperkalaemia episodes were defined as the number of serum potassium measurements exceeding each threshold (
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.12402