Smoking confounds the periodontal diagnostics using saliva biomarkers

Background Smoking is a risk factor for periodontal disease because of its complex impact on the inflammatory response in the periodontium. We investigated the effect of smoking on salivary periodontal biomarkers, matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of metalloproteinase (TIMP)‐...

Full description

Saved in:
Bibliographic Details
Published in:Journal of periodontology (1970) 2019-05, Vol.90 (5), p.475-483
Main Authors: Lahdentausta, Laura, Paju, Susanna, Mäntylä, Päivi, Buhlin, Kåre, Pietiäinen, Milla, Tervahartiala, Taina, Nieminen, Markku S., Sinisalo, Juha, Sorsa, Timo, Pussinen, Pirkko J.
Format: Article
Language:English
Subjects:
Biomarkers
Dentistry
Humans
Matrix Metalloproteinase 8
matrix metalloproteinase(s)
Medicin och hälsovetenskap
Periodontitis
Saliva
Smoking
Tissue Inhibitor of Metalloproteinase-1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Smoking is a risk factor for periodontal disease because of its complex impact on the inflammatory response in the periodontium. We investigated the effect of smoking on salivary periodontal biomarkers, matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO). Methods Saliva biomarkers were analyzed in the Parogene population (n = 480) comprising a random cohort of patients that have undergone coronary angiography and oral examination. The effect of time since cessation and pack years of smoking on biomarkers were investigated. Results Saliva MMP‐8, MMP‐9, TIMP‐1, and MPO concentrations distinguished periodontitis patients significantly from patients without periodontitis. When the time since cessation was considered, the area‐under‐the‐curve values (p‐value) for periodontitis were 0.76 (
ISSN:0022-3492
1943-3670
1943-3670
DOI:10.1002/JPER.18-0545