Low expression of NCOA5 predicts poor prognosis in human cervical cancer and promotes proliferation, migration, and invasion of cervical cancer cell lines by regulating notch3 signaling pathway

Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α–modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular biochemistry 2019-04, Vol.120 (4), p.6237-6249
Main Authors: Liang, Ying, Zhang, Tianli, Shi, Mengdie, Zhang, Shuo, Guo, Yaxing, Gao, Jiwei, Yang, Xingsheng
Format: Article
Language:English
Subjects:
Cancer
Cell proliferation
Cervical cancer
Cervix
Depletion
Estrogens
Gene expression
Gynecology
Human papillomavirus
Medical prognosis
notch3
nuclear receptor coactivator 5
Obstetrics
oncogenesis
Oncomine database
poor prognosis
Prognosis
Proteins
Regression analysis
Ribonucleic acid
RNA
Signal transduction
Signaling
Squamous cell carcinoma
Survival
Tissues
Transcription
Tumor cell lines
Tumor suppressor genes
Tumorigenicity
Tumors
Xenografts
Xenotransplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α–modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expression of NCOA5 changed in the development of human cervical cancer and its association with clinicopathological features, prognosis, and biology characteristics of cervical cancer. Analysis of the microarrays in the Oncomine database indicated that NCOA5 expression was lower in human cervical squamous cell carcinoma tissues than that in normal cervical tissues. That was corroborated by our experiments using fresh tissues: the expression levels of NCOA5 messenger RNA and protein were both significantly decreased in cervical cancer tissues compared with paired adjacent nontumor tissues (P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.27911