Serum cytokine measurements and biological therapy of psoriasis – Prospects for personalized treatment?

Psoriasis is an immune‐mediated disease where the IL‐23/Th17 axis as well as TNF comprise main targets of biological therapy. Immune profiling has so far not been embraced as a clinical tool. We aimed to investigate relationships between individual serum cytokine levels in 40 psoriasis patients befo...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2018-12, Vol.88 (6), p.e12725-n/a
Main Authors: Solberg, Silje M., Sandvik, Lene F., Eidsheim, Marianne, Jonsson, Roland, Bryceson, Yenan T., Appel, Silke
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Cytokines
Cytokines - blood
Disease Progression
Female
Helper cells
Humans
Immunotherapy
Immunotherapy - methods
Infliximab - therapeutic use
Interleukin-17 - blood
Lymphocytes T
Male
Medical treatment
Medicin och hälsovetenskap
Middle Aged
Patients
Precision Medicine
Prognosis
Psoriasis
Psoriasis - diagnosis
Psoriasis - drug therapy
Psoriasis - immunology
Quality of Life
Severity of Illness Index
Treatment Outcome
Tumor necrosis factor
Tumor Necrosis Factor-alpha - immunology
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Summary:Psoriasis is an immune‐mediated disease where the IL‐23/Th17 axis as well as TNF comprise main targets of biological therapy. Immune profiling has so far not been embraced as a clinical tool. We aimed to investigate relationships between individual serum cytokine levels in 40 psoriasis patients before and after receiving biological therapy and Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI). Serum concentration of 25 cytokines was determined by Luminex technology. Mean PASI and DLQI decreased by 71% and 65%, respectively. Increase of IL‐2 positively correlated with improvement of PASI and DLQI. Moreover, increase of IL‐5, IL‐10, IL‐12, IL‐22 and GM‐CSF correlated with treatment effect. Notably, logistic regression revealed four times higher risk of having severe psoriasis when IL‐17A increased by 1 pg/mL (OR: 4.06, P 
ISSN:0300-9475
1365-3083
1365-3083
DOI:10.1111/sji.12725