Inflammatory markers in women with postpartum depressive symptoms

Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in p...

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Bibliographic Details
Published in:Journal of neuroscience research 2020-07, Vol.98 (7), p.1309-1321
Main Authors: Bränn, Emma, Fransson, Emma, White, Richard A., Papadopoulos, Fotios C., Edvinsson, Åsa, Kamali‐Moghaddam, Masood, Cunningham, Janet L., Sundström‐Poromaa, Inger, Skalkidou, Alkistis
Format: Article
Language:English
Subjects:
Adaptability
Biomarkers
Cell- och molekylärbiologi
Chemokines
cytokines
Fibroblast growth factor 23
Growth factors
Hepatocyte growth factor
Immune response
Immune system
Inflammation
Interleukins
Klinisk medicin
maternal depression
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Mental depression
Postpartum
Postpartum depression
pregnancy
Prenatal depression
protein markers
Psykiatri
Regression analysis
Reproduktionsmedicin och gynekologi
TRANCE protein
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Summary:Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression is not as well studied. The aim of this study was to investigate the alterations in peripheral levels of inflammatory biomarkers in 169 Swedish women with and without depressive symptoms according to the Edinburgh postnatal depression scale or the M.I.N.I neuropsychiatric interview at eight weeks postpartum. Among the 70 markers analyzed with multiplex proximity extension assay, five were significantly elevated in women with postpartum depressive symptoms in the adjusted LASSO logistic regression analysis: Tumor necrosis factor ligand superfamily member (TRANCE) (OR‐per 1 SD increase = 1.20), Hepatocyte growth factor (HGF) (OR = 1.17) Interleukin (IL)‐18 (OR = 1.06), Fibroblast growth factor 23 (FGF‐23) (OR = 1.25), and C‐X‐C motif chemokine 1 (CXCL1) (OR 1.11). These results indicate that women with PPD have elevated levels of some inflammatory biomarkers. It is, therefore, plausible that PPD is associated with a compromised adaptability of the immune system.
ISSN:0360-4012
1097-4547
1097-4547
DOI:10.1002/jnr.24312