Genome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome

Background We conducted a genome-wide scan to identify non-synonymous SNPs (nsSNPs) that might influence survival after a diagnosis of colorectal cancer (CRC). Methods We genotyped 7679 nsSNPs in 1939 Scottish patients from the Scottish Colorectal Cancer Study recruited soon after a CRC diagnosis an...

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Bibliographic Details
Published in:British journal of cancer 2018-10, Vol.119 (8), p.988-993
Main Authors: Theodoratou, Evropi, Farrington, Susan M, Timofeeva, Maria, Din, Farhat VN, Svinti, Victoria, Tenesa, Albert, Liu, Tao, Lindblom, Annika, Gallinger, Steven, Campbell, Harry, Dunlop, Malcolm G
Format: Article
Language:English
Subjects:
692/4028/67/2324
692/4028/67/68
Amino Acid Sequence - genetics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Diagnosis
Drug Resistance
Epidemiology
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - methods
Genomes
Heredity
Humans
Medical prognosis
Molecular Medicine
Oncology
Polymorphism, Single Nucleotide - genetics
Prognosis
Prospective Studies
Rectum
Replication
Risk Factors
Scotland
Statistical models
Survival
Survival Analysis
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Summary:Background We conducted a genome-wide scan to identify non-synonymous SNPs (nsSNPs) that might influence survival after a diagnosis of colorectal cancer (CRC). Methods We genotyped 7679 nsSNPs in 1939 Scottish patients from the Scottish Colorectal Cancer Study recruited soon after a CRC diagnosis and prospectively followed for survival outcomes. All-cause and CRC-specific survival analyses were conducted using Cox proportional hazard models adjusted for stage, age and sex for all cancer cases, after cancer type stratification and assuming additive and recessive models of inheritance. For all the SNPs that had a p -value 
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-018-0117-7