The schizophrenia and bipolar twin study in Sweden (STAR)

The schizophrenia and bipolar twin study in Sweden (STAR) is a large nation-wide cohort of monozygotic (MZ) and dizygotic (DZ) same-sex twins with schizophrenia or bipolar disorder and healthy control pairs, extensively characterized with brain imaging, neuropsychological tests, biomarkers, genetic...

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Bibliographic Details
Published in:Schizophrenia research 2019-02, Vol.204, p.183-192
Main Authors: Johansson, Viktoria, Hultman, Christina M., Kizling, Isabelle, Martinsson, Lennart, Borg, Jacqueline, Hedman, Anna, Cannon, Tyrone D.
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarker
Biomarkers
Bipolar Disorder - diagnostic imaging
Bipolar Disorder - etiology
Bipolar Disorder - genetics
Bipolar Disorder - physiopathology
Cohort Studies
Endophenotype
Endophenotypes
Etiology
Female
Gene-Environment Interaction
Humans
Male
Medicin och hälsovetenskap
Middle Aged
Neuroimaging
Psychiatry
Registries
Research Design
Schizophrenia - diagnostic imaging
Schizophrenia - etiology
Schizophrenia - genetics
Schizophrenia - physiopathology
Sweden
Young Adult
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Summary:The schizophrenia and bipolar twin study in Sweden (STAR) is a large nation-wide cohort of monozygotic (MZ) and dizygotic (DZ) same-sex twins with schizophrenia or bipolar disorder and healthy control pairs, extensively characterized with brain imaging, neuropsychological tests, biomarkers, genetic testing, psychiatric symptoms and personality traits. The purpose is to investigate genetic and environmental mechanisms that give rise to schizophrenia and bipolar disorder as well as the intermediate phenotypes. This article describes the design, recruitment, data collection, measures, collected twins' characteristics, diagnostic procedures as well as ongoing and planned analyses. Identification of biomarkers, genetic and epigenetic variation and the development of specific and common endophenotypes for schizophrenia and bipolar disorder are potential gains from this cohort.
ISSN:0920-9964
1573-2509
1573-2509
DOI:10.1016/j.schres.2018.08.001