A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status

• Published in: Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2018-10, Vol.27 (10), p.1231-1233
• Main Authors: Stopsack, Konrad H, Gonzalez-Feliciano, Amparo G, Peisch, Samuel F, Downer, Mary K, Gage, Riley A, Finn, Stephen, Lis, Rosina T, Graff, Rebecca E, Pettersson, Andreas, Pernar, Claire H, Loda, Massimo, Kantoff, Philip W, Ahearn, Thomas U, Mucci, Lorelei A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Aspirin - therapeutic use; Follow-Up Studies; Humans; Incidence; Male; Medicin och hälsovetenskap; Middle Aged; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - metabolism; Prognosis; Prospective Studies; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; United States - epidemiology
• ISSN: 1055-9965; 1538-7755; 1538-7755
• DOI: 10.1158/1055-9965.EPI-18-0510

In a case-control study, aspirin use was associated with a lower risk of a common prostate cancer molecular subtype, the gene fusion. We sought to validate this finding in a prospective cohort. In the Health Professionals Follow-up Study, 49,395 men reported on aspirin use on biennial questionnaires and were followed for prostate cancer incidence over 23 years. status was assessed by IHC for presence of ERG on archival tumor specimens for 912 patients with prostate cancer, of whom 48% were ERG-positive. In multivariable models, we found no association between regular use of aspirin and risk of -positive prostate cancer (HR, 1.02; 95% confidence interval, 0.85-1.23), nor any association with duration or frequency of aspirin use. In restricting to cases with either high Gleason grade or advanced stage disease, there remained no association with aspirin use. Data from this prospective study with repeated assessments of aspirin use do not support the hypothesis that aspirin use is associated with a lower risk of -positive prostate cancer. Aspirin use is unlikely to lower the risk of this common molecular subtype of prostate cancer. However, there is emerging data supporting the role of other lifestyle and genetic factors underlying the development of the fusion. .