Saliva and serum biomarkers in periodontitis and coronary artery disease

Aim Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodon...

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Bibliographic Details
Published in:Journal of clinical periodontology 2018-09, Vol.45 (9), p.1045-1055
Main Authors: Lahdentausta, Laura S. J., Paju, Susanna, Mäntylä, Päivi, Buhlin, Kåre, Tervahartiala, Taina, Pietiäinen, Milla, Alfthan, Henrik, Nieminen, Markku S., Sinisalo, Juha, Sorsa, Timo, Pussinen, Pirkko J.
Format: Article
Language:English
Subjects:
acute coronary syndrome
Acute coronary syndromes
Angiography
Arteriosclerosis
biomarker
Biomarkers
Cardiovascular disease
Coronary artery
Dentistry
Diagnosis
Extracellular matrix
Gum disease
Heart diseases
Matrix metalloproteinase
Medicin och hälsovetenskap
Metalloproteinase
MMP‐8
MMP‐9
myeloperoxidase
Periodontitis
Periodontium
Peroxidase
Plaques
Saliva
serum
TIMP‐1
Tissue inhibitor of metalloproteinases
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Summary:Aim Matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of matrix metalloproteinase (TIMP)‐1 and myeloperoxidase (MPO) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodontitis and acute coronary syndrome (ACS). Materials and methods The population was PAROGENE (n = 481), a random cohort of patients with an indication for coronary angiography. All patients underwent a clinical and radiographic oral examination. Groups consisting of periodontitis versus non‐periodontitis, and ACS versus non‐ACS patients were compared. Results Saliva MMP‐8, MMP‐9 and MPO provided significant area‐under‐curve (AUC) values for periodontitis, 0.69 (
ISSN:0303-6979
1600-051X
1600-051X
DOI:10.1111/jcpe.12976