Phenotypic and functional alterations of myeloid‐derived suppressor cells during the disease course of multiple sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system involving dysregulated encephalitogenic T cells. Myeloid‐derived suppressor cells (MDSCs) have been recognized for their important function in regulating T‐cell responses. Recent studies have indicated a role for M...

Full description

Saved in:
Bibliographic Details
Published in:Immunology and cell biology 2018-09, Vol.96 (8), p.820-830
Main Authors: Iacobaeus, Ellen, Douagi, Iyadh, Jitschin, Regina, Marcusson‐Ståhl, Maritha, Andrén, Anton Törnqvist, Gavin, Caroline, Lefsihane, Katia, Davies, Lindsay C, Mougiakakos, Dimitrios, Kadri, Nadir, Le Blanc, Katarina
Format: Article
Language:English
Subjects:
Adult
Antigens, CD - metabolism
Cell Proliferation
Cells, Cultured
Cytokines - metabolism
Disease Progression
Female
Humans
Immunomodulation
Immunophenotyping
Immunotherapy - trends
Male
Medicin och hälsovetenskap
Middle Aged
Multiple Sclerosis - immunology
multiple sclerosis disease course
Myeloid-Derived Suppressor Cells - immunology
Myeloid-Derived Suppressor Cells - transplantation
myeloid‐derived suppressor cells
relapsing‐remitting multiple sclerosis
secondary progressive multiple sclerosis
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Regulatory - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system involving dysregulated encephalitogenic T cells. Myeloid‐derived suppressor cells (MDSCs) have been recognized for their important function in regulating T‐cell responses. Recent studies have indicated a role for MDSCs in autoimmune diseases, but their significance in MS is not clear. Here, we assessed the frequencies of CD14+HLA‐DRlow monocytic MDSCs (Mo‐MDSCs) and CD33+CD15+CD11b+HLA‐DRlow granulocytic MDSCs (Gr‐MDSCs) and investigated phenotypic and functional differences of Mo‐MDSCs at different clinical stages of MS and in healthy subjects (HC). Increased frequencies of Mo‐MDSCs (P 
ISSN:0818-9641
1440-1711
1440-1711
DOI:10.1111/imcb.12042