Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis

Background We studied the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy in pediatric patients with autoimmune hepatitis (AIH) who were intolerant or non-responders to standard therapy (corticosteroid and azathioprine). Patients and Methods We performed a re...

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Bibliographic Details
Published in:Digestive diseases and sciences 2018-05, Vol.63 (5), p.1348-1354
Main Authors: Efe, Cumali, Taii, Haider Al, Ytting, Henriette, Aehling, Niklas, Bhanji, Rahima A., Hagström, Hannes, Purnak, Tugrul, Muratori, Luigi, Werner, Mårten, Muratori, Paolo, Klintman, Daniel, Schiano, Thomas D., Montano-Loza, Aldo J., Berg, Thomas, Larsen, Fin Stolze, Alkhouri, Naim, Ozaslan, Ersan, Heneghan, Michael A., Yoshida, Eric M., Wahlin, Staffan
Format: Article
Language:English
Subjects:
Autoimmune hepatitis
Biochemistry
Care and treatment
Children
Chronic active hepatitis
Cirrhosis
Corticosteroids
Drug therapy
Gastroenterology
Health aspects
Hepatitis
Hepatology
Immunosuppressive agents
Liver cirrhosis
Liver transplantation
Liver transplants
Medical research
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Medicine, Experimental
Mycophenolate mofetil
Oncology
Original Article
Pediatric
Pediatrics
Second-line
Tacrolimus
Transplant Surgery
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Summary:Background We studied the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy in pediatric patients with autoimmune hepatitis (AIH) who were intolerant or non-responders to standard therapy (corticosteroid and azathioprine). Patients and Methods We performed a retrospective study of data from 13 centers in Europe, USA, and Canada. Thirty-eight patients (
ISSN:0163-2116
1573-2568
1573-2568
DOI:10.1007/s10620-018-5011-x