New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data

• Published in: Vaccine 2018-03, Vol.36 (13), p.1711-1719
• Main Authors: Shaghaghi, Mohammadreza, Soleyman-jahi, Saeed, Abolhassani, Hassan, Yazdani, Reza, Azizi, Gholamreza, Rezaei, Nima, Barbouche, Mohamed-Ridha, McKinlay, Mark A., Aghamohammadi, Asghar
• Format: Article
• Language: English
• Subjects: Animals; Bivariate analysis; Child, Preschool; Divergence; Eradication; Evolution; Excretion; Female; Genomes; History, 20th Century; History, 21st Century; Humans; Immunization; Immunocompromised Host; Immunodeficiency; Immunologic Deficiency Syndromes/complications; Immunologic Deficiency Syndromes/diagnosis; Immunology; Income; Infant; Infections; Life Sciences; Male; Medicin och hälsovetenskap; Microbiology and Parasitology; Mutation; Odds Ratio; Oral poliovirus vaccine; Paralysis; Parameter identification; Pathogenesis; Patients; Poliomyelitis; Poliomyelitis/epidemiology; Poliomyelitis/etiology; Poliomyelitis/history; Poliomyelitis/prevention & control; Poliovirus Vaccine, Oral/adverse effects; Poliovirus Vaccines/adverse effects; Poliovirus/classification; Poliovirus/genetics; Poliovirus/immunology; Primary immunodeficiencies; Primary immunodeficiency; Proportional Hazards Models; Public health; Replication; Risk factors; Serogroup; Systematic review; Vaccination/adverse effects; Vaccine-associated paralytic poliomyelitis; Vaccine-derived poliovirus; Vaccines; Vaccinology; Viral infections; Virology; Viruses
• ISSN: 0264-410X; 1873-2518; 1873-2518; 0264-410X
• DOI: 10.1016/j.vaccine.2018.02.059

•Inherent features of PID contribute to manifestations and outcome of polio infection.•Cytotoxic cellular mechanisms may contribute to the development of vaccine paralysis.•T-cell interactions with poliovirus infected cells play a role in infection clearance.•Paralysis, PID type, and income level independently influence patients’ survival.•We explained the trend of vaccine-derived poliovirus genomic evolution. Widespread administration of oral poliovirus vaccine (OPV) has decreased global incidence of poliomyelitis by ≈99.9%. However, the emergence of vaccine-derived polioviruses (VDPVs) is threatening polio-eradication program. Primary immunodeficiency (PID) patients are at higher risks of vaccine-associated paralytic poliomyelitis (VAPP) and prolonged excretion of immunodeficiency-associated VDPV (iVDPV). We searched Embase, Medline, Science direct, Scopus, Web of Science, and CDC and WHO databases by 30 September 2016, for all reports of iVDPV cases. Patient-level data were extracted form eligible studies. Data on immunization coverage and income-level of countries were extracted from WHO/UNICEF and the WORLD BANK databases, respectively. We assessed bivariate associations between immunological, clinical, and virological parameters, and exploited multivariable modeling to identify independent determinants of poliovirus evolution and patients’ outcomes. Study protocol was registered with PROSPERO (CRD42016052931). 4329 duplicate-removed titles were screened. A total of 107 iVDPV cases were identified from 68 eligible articles. The majority of cases were from higher income countries with high polio-immunization coverage. 74 (69.81%) patients developed VAPP. Combined immunodeficiency patients showed lower rates of VAPP (p